Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | HRH2 | P25021 | 2/20 | 0.38 |
| ▸ | HRH1 | P35367 | 2/20 | 0.38 |
| ▸ | BCHE | P06276 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | ESR1 | P03372 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.35 |
| ▸ | RNASEL | Q05823 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.34 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.34 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.34 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6664071 | 0.86 | PTPN1 (0.35) | SMN1; SMN2LMNAPOLBALDH1A1KMT2A | |
| SCHEMBL7740552 | 0.84 | SMN1; SMN2 (0.47) | SMN1; SMN2LMNAPOLBALDH1A1HRH2 | |
| SCHEMBL6658347 | 0.79 | ESR2 (0.43) | SMN1; SMN2LMNAALDH1A1MAPK1NR1H2 | |
| SCHEMBL27563812 | 0.77 | LMNA (0.48) | SMN1; SMN2LMNAPOLBALDH1A1HRH2 | |
| SCHEMBL9627031 | 0.76 | SMN1; SMN2 (0.50) | SMN1; SMN2LMNAPOLBALDH1A1HRH2 | |
| SCHEMBL9457164 | 0.73 | SMN1; SMN2 (0.44) | SMN1; SMN2LMNAPOLBALDH1A1HRH2 | |
| SCHEMBL574934 | 0.73 | SMN1; SMN2 (0.63) | SMN1; SMN2LMNAPOLBALDH1A1HRH2 | |
| SCHEMBL30643716 | 0.72 | HRH2 (0.47) | SMN1; SMN2LMNAPOLBHRH2HRH1 | |
| SCHEMBL29736653 | 0.71 | SMN1; SMN2 (0.44) | SMN1; SMN2LMNAPOLBALDH1A1HRH2 | |
| SCHEMBL856186 | 0.70 | SMN1; SMN2 (0.55) | SMN1; SMN2LMNAPOLBALDH1A1HRH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1080075-A4 | PIPERIDIDINYL AND N-AMIDINOPIPERIDINYL DERIVATIVES | AVENTIS PHARM PROD INC (US) | 2001-06-27 | — | — | EP | disclosed |
| EP-1080075-A1 | PIPERIDIDINYL AND N-AMIDINOPIPERIDINYL DERIVATIVES | Aventis Pharmaceuticals Products Inc. (US) | 2001-03-07 | — | — | EP | disclosed |
| WO-1999048870-A1 | PIPERIDIDINYL AND N-AMIDINOPIPERIDINYL DERIVATIVES | AVENTIS PHARMACEUTICALS PRODUCTS INC. (US) | 1999-09-30 | — | — | WO | disclosed |