Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 8/20 | 0.41 |
| ▸ | CSNK1E | P49674 | 2/20 | 0.38 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.38 |
| ▸ | MKNK1 | Q9BUB5 | 3/20 | 0.37 |
| ▸ | MKNK2 | Q9HBH9 | 3/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | KMO | O15229 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | ABL1 | P00519 | 1/20 | 0.35 |
| ▸ | BCR | P11274 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4042414 | 0.89 | CSNK1E (0.40) | P2RX7CSNK1ECSNK1DMKNK1MKNK2 | |
| SCHEMBL4041706 | 0.87 | CSNK1E (0.42) | P2RX7CSNK1EMEN1KMT2A | |
| SCHEMBL7946402 | 0.81 | KMT2A (0.43) | P2RX7MKNK1MKNK2CYP2C9KMO | |
| SCHEMBL6673137 | 0.78 | CSNK1E (0.47) | CSNK1ECSNK1D | |
| SCHEMBL4045206 | 0.77 | CSNK1E (0.47) | CSNK1ECSNK1D | |
| SCHEMBL4045215 | 0.76 | CYP11B1 (0.43) | P2RX7ABL1BCR | |
| SCHEMBL4039015 | 0.75 | GBA1 (0.47) | P2RX7CSNK1ECSNK1D | |
| SCHEMBL14368436 | 0.74 | CSNK1E (0.56) | CSNK1ECSNK1D | |
| SCHEMBL14368461 | 0.74 | CSNK1E (0.53) | CSNK1ECSNK1D | |
| SCHEMBL2752518 | 0.74 | MKNK1 (0.40) | P2RX7MKNK1MKNK2CYP2C9KMO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1436291-A2 | INDOLIZINES AS KINASE PROTEIN INHIBITORS | Aventis Pharma S.A. (FR) | 2004-07-14 | — | — | EP | disclosed |
| WO-2003024967-A2 | INDOLIZINES AS KINASE PROTEIN INHIBITORS | AVENTIS PHARMA S.A. (FR) | 2003-03-27 | — | — | WO | disclosed |