Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 1/20 | 0.43 |
| ▸ | GBA1 | P04062 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.40 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | NAMPT | P43490 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | GCK | P35557 | 1/20 | 0.39 |
| ▸ | CCR6 | P51684 | 1/20 | 0.38 |
| ▸ | ABL1 | P00519 | 1/20 | 0.38 |
| ▸ | BCR | P11274 | 1/20 | 0.38 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.37 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.37 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.37 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4036841 | 0.92 | CYP11B1 (0.42) | CYP11B1GBA1L3MBTL1HSD11B1LMNA | |
| SCHEMBL4036720 | 0.83 | GBA1 (0.43) | GBA1L3MBTL1LMNACYP2D6GCK | |
| SCHEMBL14394007 | 0.81 | CYP11B1 (0.41) | CYP11B1GBA1L3MBTL1HSD11B1LMNA | |
| SCHEMBL6658946 | 0.76 | P2RX7 (0.41) | ABL1BCRP2RX7 | |
| SCHEMBL4047940 | 0.76 | LSS (0.37) | GBA1CYP3A4CYP2D6USP2 | |
| SCHEMBL6632666 | 0.75 | LMNA (0.47) | GBA1HSD11B1LMNACYP3A4CYP2D6 | |
| SCHEMBL4037080 | 0.73 | HTT (0.48) | GBA1LMNAALDH1A1USP2GAA | |
| SCHEMBL14393987 | 0.72 | TRPV1 (0.52) | — | |
| SCHEMBL4041961 | 0.72 | PKM (0.47) | GBA1ALDH1A1USP2GAAHPGD | |
| SCHEMBL4044206 | 0.72 | KMT2A (0.42) | ALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1436291-B1 | INDOLIZINES AS KINASE PROTEIN INHIBITORS | AVENTIS PHARMA SA (FR) | 2009-01-14 | — | — | EP | disclosed |