Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | RORC | P51449 | 2/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | AVPR2 | P30518 | 1/20 | 0.39 |
| ▸ | OXTR | P30559 | 1/20 | 0.39 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.39 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.39 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.39 |
| ▸ | CYP11B2 | P19099 | 4/20 | 0.38 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | KMO | O15229 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7954864 | 0.91 | CYP11B2 (0.42) | KMT2AKDM4EMEN1CYP2C9AVPR2 | |
| SCHEMBL895772 | 0.89 | MKNK1 (0.41) | KMT2AMEN1CYP2C9AVPR2OXTR | |
| SCHEMBL7955055 | 0.86 | KMT2A (0.55) | KMT2AMEN1CYP11B2P2RX7ALDH1A1 | |
| SCHEMBL7957097 | 0.86 | KMT2A (0.43) | KMT2AKDM4EMEN1CYP2C9AVPR2 | |
| SCHEMBL7946379 | 0.86 | CYP11B2 (0.42) | KMT2AKDM4EMEN1MKNK1MKNK2 | |
| SCHEMBL7946425 | 0.86 | KDM4E (0.49) | KMT2AKDM4EMEN1CYP2C9AVPR2 | |
| SCHEMBL9710973 | 0.85 | KMT2A (0.60) | KMT2AKDM4EMEN1CYP2C9MKNK1 | |
| SCHEMBL6658946 | 0.81 | P2RX7 (0.41) | KMT2AMEN1CYP2C9MKNK1MKNK2 | |
| SCHEMBL7954909 | 0.79 | MKNK1 (0.41) | KMT2AMEN1CYP2C9AVPR2OXTR | |
| SCHEMBL8325325 | 0.78 | CYP11B2 (0.39) | KDM4ECYP2C9MKNK1MKNK2CYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6194426-B1 | CONTROLLING TUMOR NECROSIS FACTOR | RHONA-POULENC RORER S.A. (FR) | 2001-02-27 | — | — | US | claimed |
| US-6194426-B1 | CONTROLLING TUMOR NECROSIS FACTOR | RHONA-POULENC RORER S.A. (FR) | 2001-02-27 | — | — | US | disclosed |