Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP3 | P08254 | 2/20 | 0.45 |
| ▸ | MMP1 | P03956 | 1/20 | 0.45 |
| ▸ | MMP9 | P14780 | 1/20 | 0.45 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.45 |
| ▸ | PPARG | P37231 | 1/20 | 0.41 |
| ▸ | PPARA | Q07869 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | MMP8 | P22894 | 1/20 | 0.40 |
| ▸ | REN | P00797 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | CTSS | P25774 | 1/20 | 0.39 |
| ▸ | CTSK | P43235 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6659518 | 1.00 | MMP3 (0.45) | MMP3MMP1MMP9GRIK1PPARG | |
| SCHEMBL6987281 | 1.00 | MMP3 (0.45) | MMP3MMP1MMP9GRIK1PPARG | |
| SCHEMBL6943292 | 1.00 | MMP3 (0.45) | MMP3MMP1MMP9GRIK1PPARG | |
| SCHEMBL6943287 | 1.00 | MMP3 (0.45) | MMP3MMP1MMP9GRIK1PPARG | |
| SCHEMBL7763369 | 0.90 | LTA4H (0.48) | MMP3PPARGPPARALMNACTSK | |
| SCHEMBL7763366 | 0.90 | LTA4H (0.48) | MMP3PPARGPPARALMNACTSK | |
| SCHEMBL7837093 | 0.90 | MMP1 (0.44) | MMP3MMP1MMP9GRIK1LMNA | |
| SCHEMBL7837095 | 0.90 | MMP1 (0.44) | MMP3MMP1MMP9GRIK1LMNA | |
| SCHEMBL7853162 | 0.87 | MMP1 (0.46) | MMP3MMP1MMP9GRIK1MMP8 | |
| SCHEMBL7827850 | 0.87 | MMP1 (0.46) | MMP3MMP1MMP9GRIK1MMP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0832875-B1 | HIGHLY WATER-SOLUBLE METALLOPROTEINASE INHIBITOR | DAIICHI FINE CHEM CO LTD (JP) | 2004-06-30 | — | — | EP | disclosed |
| EP-1089964-B1 | HYDRAZINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2003-10-29 | — | — | EP | disclosed |
| EP-1179529-A1 | NOVEL HYDROXAMIC ACID DERIVATIVES | Daiichi Fine Chemical Co., Ltd. (JP) | 2002-02-13 | — | — | EP | disclosed |
| US-6284914-B1 | HYDROXAMIC ACID DERIVATIVES | FUJI YAKUHIN KOGYO KABUSHIKI KAISHA (JP) | 2001-09-04 | — | — | US | disclosed |
| US-6239151-B1 | TREATMENT OF INFLAMMATORY AND AUTOIMMUNE DISEASES, OSTEOARTHRITIS, RESPIRATORY DISEASES, TUMORS, CACHEXIA, CARDIOVASCULAR DISEASES, FEVER, HAEMORRHAGE AND SEPSIS, HYDRAZINE DERIVATIVES, | HOFFMANN-LA ROCHE INC. | 2001-05-29 | — | — | US | disclosed |
| EP-1101492-A1 | NOVEL REMEDIES FOR ALLERGIC DISEASES | FUJI YAKUHIN KOGYO KABUSHIKI KAISHA (JP) | 2001-05-23 | — | — | EP | disclosed |
| EP-1089964-A1 | HYDRAZINE DERIVATIVES | F.HOFFMANN-LA ROCHE AG (CH) | 2001-04-11 | — | — | EP | disclosed |
| US-6147114-A | HYDROXAMIC ACID DERIVATIVES FROM TUMOR NECROSIS FACTOR CONVERTING ENZYME | FUJI YAKUHIN KOGYO KABUSHIKI KAISHA (JP) | 2000-11-14 | — | — | US | disclosed |
| EP-1038864-A1 | NOVEL METALLOPROTEINASE INHIBITORS | FUJI YAKUHIN KOGYO KABUSHIKI KAISHA (JP) | 2000-09-27 | — | — | EP | disclosed |
| WO-2000000465-A1 | HYDRAZINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2000-01-06 | — | — | WO | disclosed |
| EP-0832875-A1 | HIGHLY WATER-SOLUBLE METALLOPROTEINASE INHIBITOR | FUJI YAKUHIN KOGYO KABUSHIKI KAISHA (JP) | 1998-04-01 | — | — | EP | disclosed |