Known targets — ChEMBL curated mechanism
ADRB1ADRB2ATP4AATP4BAXLCHRM2CHRM3DRD2FLT3HRH1HTR2AHTR2BHTR2CKCNH2KMT2AMAP2K1MAP2K2MEN1MLNRPLK4RENS1PR1SLC6A2SLC6A4atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.37 |
| ▸ | SLC6A4 known ✓ | P31645 | 1/20 | 0.37 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.44 |
| ▸ | P2RX3 | P56373 | 3/20 | 0.40 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | HTT | P42858 | 3/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | CRHBP | P24387 | 1/20 | 0.39 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | NOS2 | P35228 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL6661465 | 1.00 | GPR119 (0.44) | GPR119P2RX3FFAR1KDM4EALDH1A1 | |
| Fumaric Acid SCHEMBL5346059 | 0.94 | GPR119 (0.48) | GPR119P2RX3FFAR1KDM4EALDH1A1 | |
| Fumaric Acid SCHEMBL5346064 | 0.94 | GPR119 (0.48) | GPR119P2RX3FFAR1KDM4EALDH1A1 | |
| SCHEMBL5342961 | 0.85 | GPR119 (0.53) | GPR119KDM4EALDH1A1HTTTDP1 | |
| Fumaric Acid SCHEMBL6817583 | 0.84 | MAOA (0.40) | P2RX3FFAR1KDM4EALDH1A1ATM | |
| Fumaric Acid SCHEMBL6817580 | 0.84 | MAOA (0.40) | P2RX3FFAR1KDM4EALDH1A1ATM | |
| SCHEMBL5340211 | 0.83 | GPR119 (0.54) | GPR119KDM4EALDH1A1HTTTDP1 | |
| SCHEMBL6655200 | 0.77 | GPR119 (0.54) | GPR119KDM4EALDH1A1HTTTDP1 | |
| Fumaric Acid SCHEMBL5343190 | 0.77 | AR (0.43) | P2RX3FFAR1KDM4EALDH1A1 | |
| Fumaric Acid SCHEMBL5343195 | 0.77 | AR (0.43) | P2RX3FFAR1KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1434756-A1 | NOVEL COMPOUNDS | AstraZeneca AB (SE) | 2004-07-07 | — | — | EP | disclosed |
| WO-2003029185-A1 | NOVEL COMPOUNDS | ASTRAZENECA AB (SE) | 2003-04-10 | — | — | WO | disclosed |