Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.33 |
| ▸ | NOS1 | P29475 | 3/20 | 0.33 |
| ▸ | AXL | P30530 | 1/20 | 0.33 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.32 |
| ▸ | FLT3 | P36888 | 1/20 | 0.32 |
| ▸ | PLK3 | Q9H4B4 | 1/20 | 0.32 |
| ▸ | AR | P10275 | 1/20 | 0.31 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.30 |
| ▸ | MEN1 | O00255 | 2/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6661467 | 0.80 | CHEK1 (0.46) | NOS1AXLCHEK1FLT3PLK3 | |
| SCHEMBL6662853 | 0.76 | CSF1R (0.50) | FLT3MAPTGAAKDM4EMEN1 | |
| SCHEMBL30896407 | 0.76 | GPR3 (0.45) | NOS1CHEK1FLT3PLK3CYP1A2 | |
| SCHEMBL6918858 | 0.76 | GPR3 (0.45) | NOS1CHEK1FLT3PLK3CYP1A2 | |
| SCHEMBL6917745 | 0.72 | IDO1 (0.41) | CYP1A2MAPTKDM4EALDH1A1CYP3A4 | |
| SCHEMBL6919278 | 0.70 | ENPP1 (0.43) | MAPTGAAKDM4EMEN1KMT2A | |
| SCHEMBL6920865 | 0.68 | SERPINE1 (0.41) | MAPTGAAALDH1A1SMN1; SMN2 | |
| SCHEMBL6921370 | 0.65 | JAK2 (0.41) | CHEK1ALDH1A1TSHRFGFR1FLT1 | |
| SCHEMBL6915290 | 0.65 | JAK2 (0.41) | CHEK1FGFR1KDR | |
| SCHEMBL15515226 | 0.65 | CHEK1 (0.38) | CHEK1FLT3PLK3ARCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004016615-A1 | PYRAZOLO (4,3c) CINNOLINE COMPOUNDS AS INHIBITORS OF ITK KINASE ACTIVITY | ASTRAZENECA AB (SE) | 2004-02-26 | — | — | WO | claimed |
| WO-2004016270-A1 | USE OF Itk INHIBITORS FOR THE TREATMENT OF MAST CELL-DRIVEN OR BASOPHIL-DRIVEN DISEASES | ASTRAZENECA AB (SE) | 2004-02-26 | — | — | WO | disclosed |
| WO-2004016615-A1 | PYRAZOLO (4,3c) CINNOLINE COMPOUNDS AS INHIBITORS OF ITK KINASE ACTIVITY | ASTRAZENECA AB (SE) | 2004-02-26 | — | — | WO | disclosed |