Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Histidine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Histidine SCHEMBL9294080 | 0.92 | MC4R (0.31) | — | |
| Glutamic Acid SCHEMBL6661749 | 0.90 | — | — | |
| Histidine SCHEMBL6664452 | 0.88 | CMA1 (0.32) | — | |
| Histidine SCHEMBL27660746 | 0.88 | SLC7A5 (0.31) | — | |
| Histidine SCHEMBL1543511 | 0.88 | CYP3A4 (0.30) | — | |
| Histidine SCHEMBL27660744 | 0.88 | CYP3A4 (0.30) | — | |
| Histidine SCHEMBL9031033 | 0.87 | CRHR1 (0.32) | — | |
| Histidine SCHEMBL17685559 | 0.86 | GSR (0.33) | — | |
| Histidine SCHEMBL19809592 | 0.86 | — | — | |
| Histidine SCHEMBL8896151 | 0.86 | CRHR1 (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0840126-B1 | Marker and immunological reagent for dialysis-related amyloidosis, diabetes mellitus and diabetes mellitus complications | TOKUYAMA CORP (JP) | 2004-09-01 | — | — | EP | disclosed |
| US-6033862-A | Marker and immunological reagent for dialysis-related amyloidosis, diabetes mellitus and diabetes mellitus complications | TOKUYAMA CORPORATION (JP) | 2000-03-07 | — | — | US | disclosed |