Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP1 | P29466 | 4/20 | 0.47 |
| ▸ | CASP3 | P42574 | 4/20 | 0.47 |
| ▸ | CASP7 | P55210 | 4/20 | 0.47 |
| ▸ | CASP6 | P55212 | 4/20 | 0.47 |
| ▸ | CASP8 | Q14790 | 4/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6665539 | 0.87 | SMN1; SMN2 (0.39) | CASP1CASP3CASP7CASP6CASP8 | |
| SCHEMBL6664985 | 0.85 | CASP1 (0.40) | CASP1CASP3CASP7CASP6CASP8 | |
| SCHEMBL7538573 | 0.83 | CASP1 (0.51) | CASP1CASP3CASP7CASP6CASP8 | |
| SCHEMBL6664458 | 0.82 | TSHR (0.42) | SMN1; SMN2TSHRKMT2AMEN1ALDH1A1 | |
| SCHEMBL6532390 | 0.81 | CASP1 (0.49) | CASP1CASP3CASP7CASP6CASP8 | |
| SCHEMBL6661824 | 0.78 | ALDH1A1 (0.39) | SMN1; SMN2MAPTTSHRKMT2AMEN1 | |
| SCHEMBL6479150 | 0.69 | CASP1 (0.52) | CASP1CASP3CASP7CASP6CASP8 | |
| SCHEMBL6478370 | 0.68 | KMT2A (0.47) | CASP1CASP3CASP7CASP6CASP8 | |
| SCHEMBL6472835 | 0.68 | CASP1 (0.51) | CASP1CASP3CASP7CASP6CASP8 | |
| SCHEMBL6474104 | 0.67 | KMT2A (0.45) | CASP1CASP3CASP7CASP6CASP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1140837-B1 | COMPOUNDS USEFUL IN THE TREATMENT OF INFLAMMATORY DISEASES | GLAXO GROUP LTD (GB) | 2004-08-18 | — | — | EP | claimed |
| EP-1140837-B1 | COMPOUNDS USEFUL IN THE TREATMENT OF INFLAMMATORY DISEASES | GLAXO GROUP LTD (GB) | 2004-08-18 | — | — | EP | disclosed |
| EP-1140837-A1 | COMPOUNDS USEFUL IN THE TREATMENT OF INFLAMMATORY DISEASES | GLAXO GROUP LIMITED (GB) | 2001-10-10 | — | — | EP | disclosed |
| WO-2000037444-A1 | COMPOUNDS USEFUL IN THE TREATMENT OF INFLAMMATORY DISEASES | GLAXO GROUP LIMITED (GB) | 2000-06-29 | — | — | WO | disclosed |