Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 1/20 | 0.42 |
| ▸ | ADAM17 | P78536 | 12/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | MMP9 | P14780 | 7/20 | 0.38 |
| ▸ | MMP13 | P45452 | 7/20 | 0.38 |
| ▸ | MMP1 | P03956 | 5/20 | 0.38 |
| ▸ | MMP2 | P08253 | 1/20 | 0.38 |
| ▸ | MMP14 | P50281 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | PPARG | P37231 | 1/20 | 0.35 |
| ▸ | PPARD | Q03181 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6656957 | 0.88 | ADAM17 (0.47) | PTGS2ADAM17RAB9ALMNAHTT | |
| SCHEMBL6656710 | 0.87 | PTGS2 (0.42) | PTGS2ADAM17RAB9ALMNAHTT | |
| SCHEMBL6655282 | 0.84 | PTGS2 (0.57) | PTGS2ADAM17 | |
| SCHEMBL6656394 | 0.82 | ADAM17 (0.43) | PTGS2ADAM17RAB9ALMNAHTT | |
| SCHEMBL6658035 | 0.81 | PTGS2 (0.39) | PTGS2ADAM17RAB9ALMNAHTT | |
| SCHEMBL6660771 | 0.80 | MMP9 (0.44) | ADAM17RAB9AALDH1A1MEN1KMT2A | |
| SCHEMBL6655284 | 0.79 | ADAM17 (0.51) | ADAM17LMNAMMP9MMP13MMP1 | |
| SCHEMBL7413914 | 0.78 | ADAM17 (0.40) | PTGS2ADAM17RAB9ALMNAHTT | |
| SCHEMBL6660831 | 0.78 | ADAM17 (0.42) | PTGS2ADAM17RAB9AALDH1A1MEN1 | |
| SCHEMBL7326200 | 0.78 | ADAM17 (0.40) | PTGS2ADAM17RAB9ALMNAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1147080-B1 | ALKYNYL CONTAINING HYDROXAMIC ACID COMPOUNDS AS TACE INHIBITORS | WYETH CORP (US) | 2004-07-21 | — | — | EP | disclosed |
| US-6340691-B1 | TREATMENT OF ARTHRITIS, TUMOR METASTASIS, TISSUE ULCERATION, ABNORMAL WOUND HEALING, PERIODONTAL DISEASE, BONE DISEASE, DIABETES (INSULIN RESISTANCE) AND HIV INFECTION | AMERICAN CYANAMID COMPANY | 2002-01-22 | — | — | US | disclosed |