Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.74 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.74 |
| ▸ | HPGD | P15428 | 2/20 | 0.74 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.74 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.74 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.74 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.74 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.74 |
| ▸ | EGFR | P00533 | 6/20 | 0.72 |
| ▸ | HTT | P42858 | 4/20 | 0.67 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.64 |
| ▸ | FYN | P06241 | 1/20 | 0.58 |
| ▸ | SRC | P12931 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 2/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.54 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.52 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.52 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27410804 | 0.85 | ALDH1A1 (0.67) | SMN1; SMN2ALDH1A1HPGDCYP1A2CYP2D6 | |
| Hydrochloric Acid SCHEMBL6182347 | 0.84 | ALDH1A1 (0.66) | SMN1; SMN2ALDH1A1HPGDCYP1A2CYP2D6 | |
| SCHEMBL6666099 | 0.82 | HTT (0.68) | SMN1; SMN2ALDH1A1HPGDCYP1A2CYP2D6 | |
| SCHEMBL5564779 | 0.82 | HTT (0.64) | SMN1; SMN2ALDH1A1HPGDCYP1A2CYP2D6 | |
| SCHEMBL6662659 | 0.80 | HTT (0.67) | SMN1; SMN2ALDH1A1HPGDCYP1A2CYP2D6 | |
| SCHEMBL5564640 | 0.80 | HTT (0.62) | SMN1; SMN2ALDH1A1HPGDCYP1A2CYP2D6 | |
| SCHEMBL6664779 | 0.79 | HTT (0.64) | SMN1; SMN2ALDH1A1HPGDCYP1A2CYP2D6 | |
| SCHEMBL6180170 | 0.79 | EGFR (0.76) | EGFR | |
| SCHEMBL2101381 | 0.79 | HTT (1.00) | SMN1; SMN2ALDH1A1HPGDEGFRHTT | |
| SCHEMBL5564611 | 0.79 | KDR (0.71) | SMN1; SMN2ALDH1A1HPGDEGFRHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004013091-A2 | 4-ANILIDO SUBSTITUTED QUINAZOLINES AND USE THEREOF AS INHIBITORS OF EPIDERMAL GROWTH FACTOR RECEPTOR KINASES | YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM (IL) | 2004-02-12 | — | — | WO | claimed |
| WO-2004013091-A2 | 4-ANILIDO SUBSTITUTED QUINAZOLINES AND USE THEREOF AS INHIBITORS OF EPIDERMAL GROWTH FACTOR RECEPTOR KINASES | YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM (IL) | 2004-02-12 | — | — | WO | disclosed |