Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 4/20 | 0.64 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.53 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | HPGD | P15428 | 3/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | EGFR | P00533 | 5/20 | 0.50 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.50 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6662883 | 0.84 | ABCG2 (0.61) | HTTMAPK1ALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL6666099 | 0.80 | HTT (0.68) | HTTMAPK1KDM4EALDH1A1CYP1A2 | |
| SCHEMBL6662890 | 0.79 | SMN1; SMN2 (0.74) | HTTMAPK1KDM4EALDH1A1CYP1A2 | |
| SCHEMBL6662659 | 0.78 | HTT (0.67) | HTTMAPK1KDM4EALDH1A1CYP1A2 | |
| SCHEMBL5564779 | 0.77 | HTT (0.64) | HTTMAPK1KDM4EALDH1A1CYP1A2 | |
| SCHEMBL2101381 | 0.76 | HTT (1.00) | HTTMAPK1KDM4EALDH1A1CLK4 | |
| SCHEMBL5564611 | 0.76 | KDR (0.71) | HTTMAPK1KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL6663910 | 0.76 | ABCG2 (0.73) | HTTMAPK1KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL5564640 | 0.75 | HTT (0.62) | HTTMAPK1KDM4EALDH1A1CYP1A2 | |
| SCHEMBL5568271 | 0.74 | HTT (0.65) | HTTMAPK1KDM4EALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004013091-A2 | 4-ANILIDO SUBSTITUTED QUINAZOLINES AND USE THEREOF AS INHIBITORS OF EPIDERMAL GROWTH FACTOR RECEPTOR KINASES | YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM (IL) | 2004-02-12 | — | — | WO | disclosed |