Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP1 | P11387 | 3/20 | 0.60 |
| ▸ | POLM | Q9NP87 | 2/20 | 0.56 |
| ▸ | POLK | Q9UBT6 | 2/20 | 0.56 |
| ▸ | POLL | Q9UGP5 | 2/20 | 0.56 |
| ▸ | POLH | Q9Y253 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | USP2 | O75604 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | CASP7 | P55210 | 2/20 | 0.46 |
| ▸ | IDO1 | P14902 | 2/20 | 0.46 |
| ▸ | CDC25B | P30305 | 2/20 | 0.46 |
| ▸ | PIN1 | Q13526 | 2/20 | 0.46 |
| ▸ | AURKA | O14965 | 1/20 | 0.46 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1287104 | 0.85 | TOP1 (0.65) | TOP1POLMPOLKPOLLPOLH | |
| SCHEMBL17439481 | 0.82 | TOP1 (0.49) | TOP1POLMPOLKPOLLPOLH | |
| SCHEMBL29117714 | 0.79 | ELANE (0.45) | TOP1KMT2AALDH1A1MAPTMEN1 | |
| SCHEMBL8622400 | 0.78 | TTR (0.56) | KMT2AALDH1A1MAPTMEN1KDM4E | |
| SCHEMBL11908091 | 0.78 | ELANE (0.39) | TOP1POLMPOLKPOLLPOLH | |
| SCHEMBL3054875 | 0.78 | POLM (0.63) | TOP1POLMPOLKPOLLPOLH | |
| SCHEMBL28633753 | 0.77 | KDM4E (0.50) | TOP1KMT2AALDH1A1MAPTMEN1 | |
| SCHEMBL19798278 | 0.76 | PIM1 (0.73) | TOP1POLMPOLKPOLLPOLH | |
| SCHEMBL17460659 | 0.76 | MAOA (0.56) | KMT2AALDH1A1MAPTMEN1KDM4E | |
| SCHEMBL10399814 | 0.76 | ELANE (0.51) | KMT2AALDH1A1KDM4EHPGDMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080300298-A1 | Honokiol Derivates For the Treatment of Proliferative Disorders | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2008-12-04 | — | — | US | disclosed |
| US-20080300298-A1 | Honokiol Derivates For the Treatment of Proliferative Disorders | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2008-12-04 | — | — | US | disclosed |
| WO-2004003609-A1 | METHOD FOR PRODUCING INTEGRATED WAVEGUIDES, POLYMER SYSTEMS FOR PRODUCING SUCH WAVEGUIDES, AND METHOD FOR PRODUCING PLANAR WAVEGUIDE CHANNELS | ATOTECH DEUTSCHLAND GMBH (DE) | 2004-01-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080300298-A1 | Honokiol Derivates For the Treatment of Proliferative Disorders | CCNK, CDK3, CCNO | TOP1 663/4885POLM 1171/4885POLK 94/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.