Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP1 | P11387 | 3/20 | 0.65 |
| ▸ | POLM | Q9NP87 | 2/20 | 0.59 |
| ▸ | POLK | Q9UBT6 | 2/20 | 0.59 |
| ▸ | POLL | Q9UGP5 | 2/20 | 0.59 |
| ▸ | POLH | Q9Y253 | 2/20 | 0.59 |
| ▸ | PIM1 | P11309 | 1/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.50 |
| ▸ | HPGD | P15428 | 3/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.50 |
| ▸ | BLM | P54132 | 3/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.50 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.50 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | USP2 | O75604 | 2/20 | 0.50 |
| ▸ | TP53 | P04637 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6662940 | 0.85 | TOP1 (0.60) | TOP1POLMPOLKPOLLPOLH | |
| SCHEMBL27369443 | 0.83 | PIM1 (0.46) | TOP1POLMPOLKPOLLPOLH | |
| SCHEMBL10378556 | 0.81 | PIM1 (0.82) | TOP1POLMPOLKPOLLPOLH | |
| SCHEMBL12827331 | 0.79 | TOP1 (1.00) | TOP1POLMPOLKPOLLPOLH | |
| SCHEMBL10394363 | 0.79 | POLM (0.63) | TOP1POLMPOLKPOLLPOLH | |
| SCHEMBL3054875 | 0.79 | POLM (0.63) | TOP1POLMPOLKPOLLPOLH | |
| SCHEMBL10395154 | 0.79 | POLM (0.63) | TOP1POLMPOLKPOLLPOLH | |
| SCHEMBL5613348 | 0.79 | ALDH1A1 (0.73) | PIM1KDM4EALDH1A1MAPK1HPGD | |
| SCHEMBL30003440 | 0.78 | TOP1 (1.00) | TOP1POLMPOLKPOLLPOLH | |
| SCHEMBL3414850 | 0.78 | TOP1 (1.00) | TOP1POLMPOLKPOLLPOLH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006107827-A1 | SKIN BONDING PROCESS | CREIGHTON UNIVERSITY (US) | 2006-10-12 | — | — | WO | claimed |
| US-20220011488-A1 | COMPOUND, POLYMERIZABLE COMPOSITION, CURED PRODUCT, OPTICAL FILM, POLARIZING PLATE, AND IMAGE DISPLAY DEVICE | FUJIFILM CORPORATION (JP) | 2022-01-13 | — | — | US | disclosed |
| CN-111233649-B | Naphthoquinone compound for resisting novel coronavirus and medical application thereof | 上海交通大学 | 2020-11-06 | — | — | CN | disclosed |
| CN-111233649-A | Naphthoquinone compound for resisting novel coronavirus and medical application thereof | 上海交通大学 | 2020-06-05 | — | — | CN | disclosed |
| US-9040713-B2 | Methods of managing blood sugar levels and compositions related thereto | EMORY UNIVERSITY (US) | 2015-05-26 | — | — | US | disclosed |
| US-20130158082-A1 | METHODS OF MANAGING BLOOD SUGAR LEVELS AND COMPOSITIONS RELATED THERETO | EMORY UNIVERSITY (US) | 2013-06-20 | — | — | US | disclosed |
| WO-2012047628-A2 | METHODS OF MANAGING BLOOD SUGAR LEVELS AND COMPOSITIONS RELATED THERETO | EMORY UNIVERSITY (US) | 2012-04-12 | — | — | WO | disclosed |
| US-20110071124-A1 | Compounds that Inhibit Production of sAPPB and AB and Uses Thereof | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2011-03-24 | — | — | US | disclosed |
| US-20090247472-A1 | TYPE 1, 4-NAPHTOQUINONE COMPOUNDS, COMPOSITIONS COMPRISING THEM AND USE OF THESE COMPOUNDS AS ANTI-CANCER AGENTS | FLUOFARMA (FR) | 2009-10-01 | — | — | US | disclosed |
| US-20090247472-A1 | TYPE 1, 4-NAPHTOQUINONE COMPOUNDS, COMPOSITIONS COMPRISING THEM AND USE OF THESE COMPOUNDS AS ANTI-CANCER AGENTS | FLUOFARMA (FR) | 2009-10-01 | — | — | US | disclosed |
| WO-2007125196-A1 | TYPE 1, 4-NAPHTOQUINONE COMPOUNDS, COMPOSITIONS COMPRISING THEM AND USE OF THESE COMPOUNDS AS ANTI-CANCER AGENTS | FLUOFARMA (FR) | 2007-11-08 | — | — | WO | disclosed |
| WO-2006107827-A1 | SKIN BONDING PROCESS | CREIGHTON UNIVERSITY (US) | 2006-10-12 | — | — | WO | disclosed |
| US-3947517-A | Stereoselective introduction of tetracyclines hydroxyl group at 12(a) position in synthesis of tetracyclines | RESEARCH CORPORATION (US) | 1976-03-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220011488-A1 | COMPOUND, POLYMERIZABLE COMPOSITION, CURED PRODUCT, OPTICAL FILM, POLARIZING PLATE, AND IMAGE DISPLAY DEVICE | PDAP1, PHOSPHO1, DAD1 | TOP1 4060/4885POLM 2824/4885POLK 3298/4885 |
| US-20110071124-A1 | Compounds that Inhibit Production of sAPPB and AB and Uses Thereof | SAP30BP, APP, BACE1 | TOP1 4689/4885POLM 2905/4885POLK 3263/4885 |
| US-20130158082-A1 | METHODS OF MANAGING BLOOD SUGAR LEVELS AND COMPOSITIONS RELATED THERETO | SLC5A1, SLC2A1, SLC5A2 | TOP1 3429/4885POLM 4609/4885POLK 4648/4885 |
| US-20090247472-A1 | TYPE 1, 4-NAPHTOQUINONE COMPOUNDS, COMPOSITIONS COMPRISING THEM AND USE OF THESE COMPOUNDS AS ANTI-CANCER AGENTS | CCNA1, MKI67, CCNT1 | TOP1 24/4885POLM 1171/4885POLK 391/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.