Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 16/20 | 0.82 |
| ▸ | DRD4 | P21917 | 5/20 | 0.82 |
| ▸ | DRD2 | P14416 | 5/20 | 0.82 |
| ▸ | DRD3 | P35462 | 5/20 | 0.82 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.82 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.82 |
| ▸ | MEN1 | O00255 | 2/20 | 0.82 |
| ▸ | LMNA | P02545 | 2/20 | 0.82 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.82 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.82 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.82 |
| ▸ | HTR2B | P41595 | 2/20 | 0.82 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.82 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.82 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.82 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.82 |
| ▸ | SCN1A | P35498 | 2/20 | 0.82 |
| ▸ | SCN2A | Q99250 | 2/20 | 0.82 |
| ▸ | SCN3A | Q9NY46 | 2/20 | 0.82 |
| ▸ | HRH2 | P25021 | 2/20 | 0.82 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14580937 | 0.91 | OPRM1 (0.82) | OPRM1DRD4DRD2DRD3ADRA2A | |
| SCHEMBL10066897 | 0.91 | OPRM1 (0.82) | OPRM1DRD4DRD2DRD3ADRA2A | |
| Loperamide SCHEMBL8409779 | 0.90 | OPRM1 (1.00) | OPRM1DRD4DRD2DRD3ADRA2A | |
| SCHEMBL6896217 | 0.90 | OPRM1 (0.81) | OPRM1DRD4DRD2DRD3ADRA2A | |
| SCHEMBL7743931 | 0.90 | OPRM1 (0.81) | OPRM1DRD4DRD2DRD3ADRA2A | |
| Loperamide SCHEMBL12387663 | 0.90 | OPRM1 (1.00) | OPRM1DRD4DRD2DRD3ADRA2A | |
| Loperamide SCHEMBL28530 | 0.90 | OPRM1 (1.00) | OPRM1DRD4DRD2DRD3ADRA2A | |
| Loperamide SCHEMBL15048 | 0.89 | OPRM1 (1.00) | OPRM1DRD4DRD2DRD3ADRA2A | |
| Water SCHEMBL8606049 | 0.89 | OPRM1 (0.79) | OPRM1DRD4DRD2DRD3ADRA2A | |
| Loperamide SCHEMBL8409268 | 0.89 | OPRM1 (1.00) | OPRM1DRD4DRD2DRD3ADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1097924-B1 | 4-hydroxy-4-phenylpiperidine derivatives having opioid agonist activity and pharmaceuticals containing the same | SSP CO LTD (JP) | 2004-08-25 | — | — | EP | disclosed |
| US-6362203-B1 | ANALGESICS | SSP CO., LTD (JP) | 2002-03-26 | — | — | US | disclosed |
| EP-1097924-A1 | 4-hydroxy-4-phenylpiperidine derivatives having -opioid agonist activity and pharmaceuticals containing the same | SSP Co., Ltd. (JP) | 2001-05-09 | — | — | EP | disclosed |