Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | TP53 | P04637 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.44 |
| ▸ | CTSK | P43235 | 1/20 | 0.42 |
| ▸ | RGS4 | P49798 | 1/20 | 0.41 |
| ▸ | RGS8 | P57771 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | MAOA | P21397 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | PDE4A | P27815 | 1/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.40 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6660040 | 0.93 | KMT2A (0.44) | KMT2AMEN1LMNAMAPTRXFP1 | |
| SCHEMBL6665236 | 0.88 | KMT2A (0.51) | KMT2AMEN1LMNARXFP1HTT | |
| SCHEMBL6666762 | 0.84 | MAPK1 (0.53) | KMT2AMEN1TP53LMNAMAPT | |
| SCHEMBL6661746 | 0.83 | KMT2A (0.44) | KMT2AMEN1TP53LMNARXFP1 | |
| SCHEMBL6662150 | 0.82 | KMT2A (0.45) | KMT2AMEN1LMNARXFP1HTT | |
| SCHEMBL6665174 | 0.82 | KMT2A (0.46) | KMT2AMEN1LMNARXFP1HTT | |
| SCHEMBL6661011 | 0.82 | POLB (0.50) | KMT2AMEN1LMNAHTTKDM4E | |
| SCHEMBL6659535 | 0.79 | LMNA (0.47) | KMT2AMEN1LMNAMAPTHTT | |
| SCHEMBL6665787 | 0.78 | SMN1; SMN2 (0.38) | KMT2AMEN1TP53LMNAMAPT | |
| SCHEMBL20989216 | 0.77 | TP53 (0.48) | KMT2AMEN1TP53LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1257552-B1 | XANTHINE DERIVATIVES, INTERMEDIATES AND USE FOR TREATING OSTEOPOROSIS | AVENTIS PHARMA SA (FR) | 2004-08-18 | — | — | EP | disclosed |