Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 3/20 | 0.37 |
| ▸ | TSHR | P16473 | 3/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6665236 | 0.83 | KMT2A (0.51) | SMN1; SMN2ALDH1A1LMNAKMT2AMEN1 | |
| SCHEMBL6659535 | 0.79 | LMNA (0.47) | SMN1; SMN2ALDH1A1LMNAKMT2AMEN1 | |
| SCHEMBL6665174 | 0.79 | KMT2A (0.46) | SMN1; SMN2ALDH1A1LMNAKMT2AMEN1 | |
| SCHEMBL6660040 | 0.79 | KMT2A (0.44) | SMN1; SMN2ALDH1A1LMNAKMT2AMEN1 | |
| SCHEMBL6666190 | 0.79 | SMN1; SMN2 (0.41) | SMN1; SMN2ALDH1A1LMNAKMT2AMEN1 | |
| SCHEMBL6663376 | 0.78 | KMT2A (0.49) | ALDH1A1LMNAKMT2AMEN1TP53 | |
| SCHEMBL6663336 | 0.78 | TAS2R8 (0.41) | SMN1; SMN2ALDH1A1NPSR1LMNAKMT2A | |
| SCHEMBL6661011 | 0.77 | POLB (0.50) | SMN1; SMN2ALDH1A1LMNAKMT2AMEN1 | |
| SCHEMBL6661746 | 0.77 | KMT2A (0.44) | SMN1; SMN2ALDH1A1LMNAKMT2AMEN1 | |
| SCHEMBL6662150 | 0.76 | KMT2A (0.45) | SMN1; SMN2ALDH1A1LMNAKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1257552-B1 | XANTHINE DERIVATIVES, INTERMEDIATES AND USE FOR TREATING OSTEOPOROSIS | AVENTIS PHARMA SA (FR) | 2004-08-18 | — | — | EP | disclosed |