Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TMEM97 | Q5BJF2 | 14/20 | 0.56 |
| ▸ | SIGMAR1 | Q99720 | 14/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.51 |
| ▸ | NPC1 | O15118 | 3/20 | 0.51 |
| ▸ | RAB9A | P51151 | 3/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | HTR1A | P08908 | 1/20 | 0.47 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.47 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.47 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.47 |
| ▸ | DRD1 | P21728 | 1/20 | 0.47 |
| ▸ | HRH2 | P25021 | 1/20 | 0.47 |
| ▸ | HTR1B | P28222 | 1/20 | 0.47 |
| ▸ | HTR2A | P28223 | 1/20 | 0.47 |
| ▸ | HTR2C | P28335 | 1/20 | 0.47 |
| ▸ | HTR1E | P28566 | 1/20 | 0.47 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2440342 | 0.82 | TMEM97 (0.57) | TMEM97SIGMAR1MEN1KMT2ANPSR1 | |
| SCHEMBL8323054 | 0.81 | TMEM97 (0.56) | TMEM97SIGMAR1MEN1KMT2ANPSR1 | |
| SCHEMBL16078941 | 0.81 | TMEM97 (0.56) | TMEM97SIGMAR1MEN1KMT2ANPSR1 | |
| SCHEMBL5109854 | 0.80 | MEN1 (0.71) | TMEM97SIGMAR1MEN1KMT2ANPSR1 | |
| SCHEMBL1000788 | 0.80 | MEN1 (0.71) | TMEM97SIGMAR1MEN1KMT2ANPSR1 | |
| SCHEMBL7424105 | 0.80 | MEN1 (0.71) | TMEM97SIGMAR1MEN1KMT2ANPSR1 | |
| SCHEMBL3602428 | 0.79 | MEN1 (0.62) | TMEM97SIGMAR1MEN1KMT2ANPSR1 | |
| SCHEMBL30793400 | 0.79 | TMEM97 (0.54) | TMEM97SIGMAR1MEN1KMT2ANPSR1 | |
| SCHEMBL13784680 | 0.79 | MEN1 (0.56) | TMEM97SIGMAR1MEN1KMT2ANPSR1 | |
| SCHEMBL30793327 | 0.79 | TMEM97 (0.54) | TMEM97SIGMAR1MEN1KMT2ANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1080075-B1 | PIPERIDIDINYL AND N-AMIDINOPIPERIDINYL DERIVATIVES | AVENTIS PHARMA INC (US) | 2004-08-11 | — | — | EP | disclosed |
| US-20040067988-A1 | Piperididinyl and N-amidinopiperidinyl derivatives | AVENTIS PHARMACEUTICALS INC. (US) | 2004-04-08 | — | — | US | disclosed |
| US-20020016339-A1 | Piperididinyl and N-amidinopiperidinyl derivatives | KLEIN SCOTT I (US) | 2002-02-07 | — | — | US | disclosed |
| US-6277865-B1 | ANTICOAGULANTS | AVENTIS PHARMACEUTICALS PRODUCTS INC. | 2001-08-21 | — | — | US | disclosed |
| EP-1080075-A4 | PIPERIDIDINYL AND N-AMIDINOPIPERIDINYL DERIVATIVES | AVENTIS PHARM PROD INC (US) | 2001-06-27 | — | — | EP | disclosed |
| EP-1080075-A1 | PIPERIDIDINYL AND N-AMIDINOPIPERIDINYL DERIVATIVES | Aventis Pharmaceuticals Products Inc. (US) | 2001-03-07 | — | — | EP | disclosed |
| WO-1999048870-A1 | PIPERIDIDINYL AND N-AMIDINOPIPERIDINYL DERIVATIVES | AVENTIS PHARMACEUTICALS PRODUCTS INC. (US) | 1999-09-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020016339-A1 | Piperididinyl and N-amidinopiperidinyl derivatives | F11, F5, TFPI | TMEM97 1923/4885SIGMAR1 2061/4885MEN1 717/4885 |
| US-20040067988-A1 | Piperididinyl and N-amidinopiperidinyl derivatives | TFPI, F2, SERPINC1 | TMEM97 3782/4885SIGMAR1 3863/4885MEN1 1300/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.