Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NCOA1 | Q15788 | 1/20 | 0.82 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.82 |
| ▸ | MAPT | P10636 | 3/20 | 0.67 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.67 |
| ▸ | HPGD | P15428 | 3/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.67 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.67 |
| ▸ | HTT | P42858 | 4/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.58 |
| ▸ | KDR | P35968 | 3/20 | 0.58 |
| ▸ | EGFR | P00533 | 7/20 | 0.58 |
| ▸ | LCK | P06239 | 3/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | NPC1 | O15118 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 1/20 | 0.56 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.53 |
| ▸ | RAF1 | P04049 | 1/20 | 0.52 |
| ▸ | BRAF | P15056 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15503743 | 0.91 | NCOA1 (1.00) | NCOA1NCOA3MAPTGRM1HPGD | |
| SCHEMBL5565146 | 0.87 | KDM4E (0.74) | NCOA1NCOA3MAPTHPGDALDH1A1 | |
| SCHEMBL3339302 | 0.81 | MAPT (1.00) | NCOA1NCOA3MAPTGRM1HTT | |
| Hydrochloric Acid SCHEMBL7417527 | 0.80 | MAPT (0.97) | NCOA1NCOA3MAPTGRM1HTT | |
| Hydrochloric Acid SCHEMBL29624330 | 0.80 | MAPT (0.97) | NCOA1NCOA3MAPTGRM1HTT | |
| SCHEMBL5570080 | 0.78 | KDM4E (0.67) | NCOA1NCOA3MAPTHPGDALDH1A1 | |
| SCHEMBL14595168 | 0.77 | EGFR (0.74) | NCOA1NCOA3MAPTGRM1HPGD | |
| SCHEMBL28469600 | 0.77 | MAPT (0.80) | NCOA1NCOA3MAPTGRM1HTT | |
| SCHEMBL11279693 | 0.77 | MAPT (0.80) | NCOA1NCOA3MAPTGRM1HTT | |
| SCHEMBL2100465 | 0.77 | MAPT (0.84) | NCOA1NCOA3MAPTGRM1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004013091-A2 | 4-ANILIDO SUBSTITUTED QUINAZOLINES AND USE THEREOF AS INHIBITORS OF EPIDERMAL GROWTH FACTOR RECEPTOR KINASES | YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM (IL) | 2004-02-12 | — | — | WO | claimed |