SCHEMBL3339302

SCHEMBL3339302

COc1ccc(Nc2ncnc3ccc(OC)cc23)cc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 1/20 1.00
GRM1 Q13255 1/20 1.00
EGFR P00533 11/20 0.84
NCOA1 Q15788 1/20 0.82
NCOA3 Q9Y6Q9 1/20 0.82
LCK P06239 4/20 0.74
ERBB2 P04626 1/20 0.73
NPC1 O15118 1/20 0.72
HTT P42858 1/20 0.72
RAB9A P51151 1/20 0.72
SMN1; SMN2 Q16637 1/20 0.72
CLK4 Q9HAZ1 2/20 0.64
BRAF P15056 2/20 0.64
MEN1 O00255 1/20 0.64
USP2 O75604 1/20 0.64
LMNA P02545 1/20 0.64
CYP1A2 P05177 1/20 0.64
CYP3A4 P08684 1/20 0.64
CYP2C9 P11712 1/20 0.64
TSHR P16473 1/20 0.64

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL29624330 0.98 MAPT (0.97) MAPTGRM1EGFRNCOA1NCOA3
Hydrochloric Acid SCHEMBL7417527 0.98 MAPT (0.97) MAPTGRM1EGFRNCOA1NCOA3
SCHEMBL2100465 0.92 MAPT (0.84) MAPTGRM1EGFRNCOA1NCOA3
SCHEMBL6954080 0.91 EGFR (1.00) MAPTGRM1EGFRNCOA1NCOA3
SCHEMBL15503743 0.90 NCOA1 (1.00) MAPTGRM1EGFRNCOA1NCOA3
SCHEMBL11279693 0.89 MAPT (0.80) MAPTGRM1EGFRNCOA1NCOA3
SCHEMBL28469600 0.89 MAPT (0.80) MAPTGRM1EGFRNCOA1NCOA3
SCHEMBL4380336 0.86 MAPT (0.76) MAPTGRM1EGFRNCOA1NCOA3
SCHEMBL22300487 0.86 MAPT (0.74) MAPTGRM1EGFRNCOA1NCOA3
SCHEMBL22300454 0.86 MAPT (0.74) MAPTGRM1EGFRNCOA1NCOA3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 74 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2010048095-A2 TREATMENT AND/OR PREVENTION OF INNER EAR CONDITIONS BY MODULATION OF A METABOTROPIC GLUTAMATE RECEPTOR HOUSE EAR INSTITUTE (US) 2010-04-29 WO claimed
US-20240358634-A1 AURIS FORMULATIONS FOR TREATING OTIC DISEASES AND CONDITIONS DOMPÉ FARMACEUTICI S.P.A. (IT) 2024-10-31 US disclosed
US-11969501-B2 Auris formulations for treating otic diseases and conditions DOMPÉ FARMACEUTICI S.P.A. (IT) 2024-04-30 US disclosed
US-11918653-B2 Triglyceride otic formulations and uses thereof DOMPÉ FARMACEUTICI S.P.A. (IT) 2024-03-05 US disclosed
US-20220040095-A1 AURIS FORMULATIONS FOR TREATING OTIC DISEASES AND CONDITIONS DOMPÉ FARMACEUTICI S.P.A. (IT) 2022-02-10 US disclosed
US-20220040096-A1 AURIS FORMULATIONS FOR TREATING OTIC DISEASES AND CONDITIONS OTONOMY INC (US) 2022-02-10 US disclosed
US-11123286-B2 Auris formulations for treating otic diseases and conditions OTONOMY, INC. (US) 2021-09-21 US disclosed
US-11123285-B2 Auris formulations for treating OTIC diseases and conditions OTONOMY, INC. (US) 2021-09-21 US disclosed
US-20210138069-A1 TRIGLYCERIDE OTIC FORMULATIONS AND USES THEREOF DOMPÉ FARMACEUTICI S.P.A. (IT) 2021-05-13 US disclosed
US-20200397907-A1 TRIGLYCERIDE OTIC FORMULATIONS AND USES THEREOF OTONOMY, INC. 2020-12-24 US disclosed
WO-2011156780-A2 8-(SULFONYLBENZYL)PYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONES FOR THE TREATMENT OF CNS DISORDERS AFRAXIS, INC. (US) 2011-12-15 WO disclosed
US-20100273864-A1 CONTROLLED RELEASE AURIS SENSORY CELL MODULATOR COMPOSITIONS AND METHODS FOR THE TREATMENT OF OTIC DISORDERS OTONOMY, INC. (US) 2010-10-28 US disclosed
WO-2010074992-A2 CONTROLLED RELEASE AURIS SENSORY CELL MODULATOR COMPOSITIONS AND METHODS FOR THE TREATMENT OF OTIC DISORDERS OTONOMY, INC. (US) 2010-07-01 WO disclosed
WO-2010071846-A2 COMPOUNDS FOR TREATING NEUROPSYCHIATRIC CONDITIONS AFRAXIS, INC. (US) 2010-06-24 WO disclosed
WO-2010062413-A1 CONTROLLED RELEASE AURIS SENSORY CELL MODULATOR COMPOSITIONS AND METHODS FOR THE TREATMENT OF OTIC DISORDERS OTONOMY, INC. (US) 2010-06-03 WO disclosed
WO-2010048095-A2 TREATMENT AND/OR PREVENTION OF INNER EAR CONDITIONS BY MODULATION OF A METABOTROPIC GLUTAMATE RECEPTOR HOUSE EAR INSTITUTE (US) 2010-04-29 WO disclosed
US-20100021416-A1 CONTROLLED-RELEASE OTIC STRUCTURE MODULATING AND INNATE IMMUNE SYSTEM MODULATING COMPOSITIONS AND METHODS FOR THE TREATMENT OF OTIC DISORDERS OTONOMY, INC. (US) 2010-01-28 US disclosed
WO-2010011605-A2 CONTROLLED-RELEASE OTIC STRUCTURE MODULATING AND INNATE IMMUNE SYSTEM MODULATING COMPOSITIONS AND METHODS FOR THE TREATMENT OF OTIC DISORDERS OTONOMY, INC. (US) 2010-01-28 WO disclosed
US-20100015263-A1 CONTROLLED RELEASE AURIS SENSORY CELL MODULATOR COMPOSITIONS AND METHODS FOR THE TREATMENT OF OTIC DISORDERS OTONOMY, INC. (US) 2010-01-21 US disclosed
US-20090306225-A1 AURIS FORMULATIONS FOR TREATING OTIC DISEASES AND CONDITIONS OTONOMY, INC. (US) 2009-12-10 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (13 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100015263-A1 CONTROLLED RELEASE AURIS SENSORY CELL MODULATOR COMPOSITIONS AND METHODS FOR THE TREATMENT OF OTIC DISORDERS OTC, MYOC, S100B MAPT 2187/4885GRM1 1952/4885EGFR 1289/4885
US-20210138069-A1 TRIGLYCERIDE OTIC FORMULATIONS AND USES THEREOF CETP, LIPA, APOB MAPT 2438/4885GRM1 4226/4885EGFR 4219/4885
US-20220040096-A1 AURIS FORMULATIONS FOR TREATING OTIC DISEASES AND CONDITIONS OTC, AQP4, SLC26A4 MAPT 2171/4885GRM1 2230/4885EGFR 1314/4885
US-11123286-B2 Auris formulations for treating otic diseases and conditions OTC, AQP4, SLC26A4 MAPT 2171/4885GRM1 2230/4885EGFR 1314/4885
US-20090306225-A1 AURIS FORMULATIONS FOR TREATING OTIC DISEASES AND CONDITIONS OTC, AQP4, SLC26A4 MAPT 2171/4885GRM1 2230/4885EGFR 1314/4885
US-11123285-B2 Auris formulations for treating OTIC diseases and conditions OTC, AQP4, SLC26A4 MAPT 2171/4885GRM1 2230/4885EGFR 1314/4885
US-11918653-B2 Triglyceride otic formulations and uses thereof CETP, LIPA, APOB MAPT 2438/4885GRM1 4226/4885EGFR 4219/4885
US-20240358634-A1 AURIS FORMULATIONS FOR TREATING OTIC DISEASES AND CONDITIONS OTC, AQP4, SLC26A4 MAPT 2171/4885GRM1 2230/4885EGFR 1314/4885
US-20100021416-A1 CONTROLLED-RELEASE OTIC STRUCTURE MODULATING AND INNATE IMMUNE SYSTEM MODULATING COMPOSITIONS AND METHODS FOR THE TREATMENT OF OTIC DISORDERS OTC, TLR3, STING1 MAPT 3025/4885GRM1 2790/4885EGFR 1547/4885
US-20200397907-A1 TRIGLYCERIDE OTIC FORMULATIONS AND USES THEREOF CETP, LIPA, APOB MAPT 2140/4885GRM1 3830/4885EGFR 3879/4885
US-20220040095-A1 AURIS FORMULATIONS FOR TREATING OTIC DISEASES AND CONDITIONS OTC, AQP4, SLC26A4 MAPT 2171/4885GRM1 2230/4885EGFR 1314/4885
US-20100273864-A1 CONTROLLED RELEASE AURIS SENSORY CELL MODULATOR COMPOSITIONS AND METHODS FOR THE TREATMENT OF OTIC DISORDERS OTC, MYOC, S100B MAPT 2187/4885GRM1 1952/4885EGFR 1289/4885
US-11969501-B2 Auris formulations for treating otic diseases and conditions OTC, AQP4, SLC26A4 MAPT 2171/4885GRM1 2230/4885EGFR 1314/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.