Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.60 |
| ▸ | RAB9A | P51151 | 3/20 | 0.60 |
| ▸ | MAPT | P10636 | 2/20 | 0.60 |
| ▸ | ESR1 | P03372 | 2/20 | 0.53 |
| ▸ | CFTR | P13569 | 1/20 | 0.51 |
| ▸ | SCN8A | Q9UQD0 | 2/20 | 0.49 |
| ▸ | SCN10A | Q9Y5Y9 | 2/20 | 0.49 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.48 |
| ▸ | IDH1 | O75874 | 1/20 | 0.47 |
| ▸ | RXFP1 | Q9HBX9 | 3/20 | 0.47 |
| ▸ | MAOA | P21397 | 1/20 | 0.46 |
| ▸ | MAOB | P27338 | 1/20 | 0.46 |
| ▸ | PTGES | O14684 | 1/20 | 0.46 |
| ▸ | APOB | P04114 | 1/20 | 0.46 |
| ▸ | MTTP | P55157 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6800635 | 0.88 | NPC1 (0.58) | NPC1RAB9AMAPTESR1CFTR | |
| SCHEMBL6669684 | 0.84 | NPC1 (0.60) | NPC1RAB9AMAPTCFTRMAOA | |
| SCHEMBL7086631 | 0.79 | NPC1 (0.54) | NPC1RAB9ARXFP1APOBMTTP | |
| SCHEMBL7133291 | 0.78 | NPC1 (0.56) | NPC1RAB9ATRPV1APOB | |
| SCHEMBL6792746 | 0.78 | PTGS1 (0.57) | NPC1RAB9AAPOBMTTP | |
| SCHEMBL6168385 | 0.78 | ESR1 (0.82) | NPC1RAB9AMAPTESR1TRPV1 | |
| SCHEMBL7087379 | 0.77 | RXFP1 (0.57) | NPC1RAB9ATRPV1RXFP1APOB | |
| SCHEMBL4761937 | 0.76 | NPC1 (1.00) | NPC1RAB9AMAPTESR1CFTR | |
| SCHEMBL31156451 | 0.76 | NPC1 (1.00) | NPC1RAB9AMAPTESR1CFTR | |
| SCHEMBL6804147 | 0.76 | NPC1 (0.58) | NPC1RAB9AMAPTCFTRMAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1383760-A1 | BIARYLCARBOXAMIDE COMPOUNDS AS APOLIPOPROTEIN B INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2004-01-28 | — | — | EP | disclosed |
| WO-2002090347-A1 | AMIDE COMPOUNDS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2002-11-14 | — | — | WO | disclosed |