Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.60 |
| ▸ | RAB9A | P51151 | 4/20 | 0.60 |
| ▸ | MAPT | P10636 | 3/20 | 0.60 |
| ▸ | CFTR | P13569 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | MAOA | P21397 | 3/20 | 0.49 |
| ▸ | MAOB | P27338 | 3/20 | 0.49 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | ATR | Q13535 | 1/20 | 0.47 |
| ▸ | PRKCI | P41743 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6804147 | 0.87 | NPC1 (0.58) | NPC1RAB9AMAPTCFTRL3MBTL1 | |
| SCHEMBL6664034 | 0.84 | NPC1 (0.60) | NPC1RAB9AMAPTCFTRMAOA | |
| SCHEMBL4761937 | 0.76 | NPC1 (1.00) | NPC1RAB9AMAPTCFTRMAOA | |
| SCHEMBL31156451 | 0.76 | NPC1 (1.00) | NPC1RAB9AMAPTCFTRMAOA | |
| SCHEMBL6800635 | 0.76 | NPC1 (0.58) | NPC1RAB9AMAPTCFTRLMNA | |
| SCHEMBL31070252 | 0.74 | NPC1 (0.67) | NPC1RAB9AMAPTCFTRMAOA | |
| SCHEMBL4347943 | 0.74 | NPC1 (0.69) | NPC1RAB9AMAPTMAOAMAOB | |
| SCHEMBL28422461 | 0.74 | NPC1 (0.50) | NPC1RAB9AMAPTCFTRMAOA | |
| SCHEMBL29765310 | 0.74 | NPC1 (0.50) | NPC1RAB9AMAPTCFTRMAOA | |
| SCHEMBL6662272 | 0.73 | L3MBTL1 (0.51) | CFTRL3MBTL1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1383760-A1 | BIARYLCARBOXAMIDE COMPOUNDS AS APOLIPOPROTEIN B INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2004-01-28 | — | — | EP | disclosed |
| WO-2002090347-A1 | AMIDE COMPOUNDS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2002-11-14 | — | — | WO | disclosed |