Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 14/20 | 0.78 |
| ▸ | ABCG2 | Q9UNQ0 | 3/20 | 0.73 |
| ▸ | JAK3 | P52333 | 3/20 | 0.73 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.73 |
| ▸ | KDR | P35968 | 7/20 | 0.71 |
| ▸ | CLK1 | P49759 | 1/20 | 0.69 |
| ▸ | LCK | P06239 | 4/20 | 0.67 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.67 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.65 |
| ▸ | GAK | O14976 | 2/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.65 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.65 |
| ▸ | ABL1 | P00519 | 1/20 | 0.65 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.65 |
| ▸ | CDK1 | P06493 | 1/20 | 0.65 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.65 |
| ▸ | FBP1 | P09467 | 1/20 | 0.65 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.65 |
| ▸ | MAPT | P10636 | 1/20 | 0.65 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5570070 | 0.88 | EGFR (0.85) | EGFRABCG2JAK3ABCB1KDR | |
| SCHEMBL5865262 | 0.85 | EGFR (0.81) | EGFRABCG2JAK3ABCB1KDR | |
| SCHEMBL29651 | 0.84 | JAK3 (1.00) | EGFRABCG2JAK3ABCB1KDR | |
| SCHEMBL14095971 | 0.84 | EGFR (0.80) | EGFRABCG2JAK3ABCB1KDR | |
| SCHEMBL20812874 | 0.84 | EGFR (0.80) | EGFRABCG2JAK3ABCB1KDR | |
| SCHEMBL29711485 | 0.84 | JAK3 (1.00) | EGFRABCG2JAK3ABCB1KDR | |
| SCHEMBL29372372 | 0.84 | JAK3 (1.00) | EGFRABCG2JAK3ABCB1KDR | |
| SCHEMBL5467825 | 0.83 | EGFR (1.00) | EGFRABCG2JAK3ABCB1KDR | |
| Hydrochloric Acid SCHEMBL5479908 | 0.82 | EGFR (0.97) | EGFRABCG2JAK3ABCB1KDR | |
| SCHEMBL5565137 | 0.82 | EGFR (1.00) | EGFRABCG2JAK3KDRCLK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004013091-A2 | 4-ANILIDO SUBSTITUTED QUINAZOLINES AND USE THEREOF AS INHIBITORS OF EPIDERMAL GROWTH FACTOR RECEPTOR KINASES | YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM (IL) | 2004-02-12 | — | — | WO | claimed |
| WO-2004013091-A2 | 4-ANILIDO SUBSTITUTED QUINAZOLINES AND USE THEREOF AS INHIBITORS OF EPIDERMAL GROWTH FACTOR RECEPTOR KINASES | YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM (IL) | 2004-02-12 | — | — | WO | disclosed |