Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.42 |
| ▸ | TFEB | P19484 | 1/20 | 0.42 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.42 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | CA4 | P22748 | 1/20 | 0.42 |
| ▸ | CA7 | P43166 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6942168 | 1.00 | HTT (0.50) | HTTALDH1A1MAPTGAANFE2L2 | |
| SCHEMBL6664578 | 1.00 | HTT (0.50) | HTTALDH1A1MAPTGAANFE2L2 | |
| SCHEMBL6942137 | 0.85 | SMN1; SMN2 (0.49) | HTTALDH1A1MAPTGAANFE2L2 | |
| SCHEMBL6942134 | 0.85 | SMN1; SMN2 (0.49) | HTTALDH1A1MAPTGAANFE2L2 | |
| SCHEMBL7464335 | 0.78 | MAPT (0.38) | HTTALDH1A1MAPTGAAPOLB | |
| SCHEMBL12656573 | 0.73 | CA1 (0.48) | HTTALDH1A1GAANFE2L2TFEB | |
| 1,2-Dimethoxybenzene SCHEMBL28118612 | 0.72 | CA1 (0.72) | HTTALDH1A1MAPTGAANFE2L2 | |
| SCHEMBL1379749 | 0.71 | NFE2L2 (0.74) | ALDH1A1MAPTNFE2L2TFEBKDM4E | |
| SCHEMBL1477685 | 0.71 | NFE2L2 (0.74) | ALDH1A1MAPTNFE2L2TFEBKDM4E | |
| SCHEMBL1477777 | 0.71 | NFE2L2 (0.74) | ALDH1A1MAPTNFE2L2TFEBKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1453828-A2 | AZABICYCLIC COMPOUNDS FOR THE TREATMENT OF FIBROMYALGIA SYNDROME | AstraZeneca AB (SE) | 2004-09-08 | — | — | EP | disclosed |
| WO-2003032897-A2 | AZABICYCLIC COMPOUNDS FOR THE TREATMENT OF FIBROMYALGIA SYNDROME | ASTRAZENECA AB (SE) | 2003-04-24 | — | — | WO | disclosed |