Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | PLIN1 | O60240 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | PLIN5 | Q00G26 | 1/20 | 0.42 |
| ▸ | ABHD5 | Q8WTS1 | 1/20 | 0.42 |
| ▸ | CCNC | P24863 | 3/20 | 0.41 |
| ▸ | CDK8 | P49336 | 3/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.38 |
| ▸ | JUN | P05412 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | DDAH1 | O94760 | 1/20 | 0.38 |
| ▸ | NOS1 | P29475 | 1/20 | 0.38 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.37 |
| ▸ | RELA | Q04206 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6664645 | 1.00 | ALDH1A1 (0.42) | ALDH1A1MAPTLMNANPSR1HTT | |
| SCHEMBL6943899 | 0.82 | ALDH1A1 (0.47) | ALDH1A1MAPTLMNANPSR1HTT | |
| SCHEMBL6943902 | 0.82 | ALDH1A1 (0.47) | ALDH1A1MAPTLMNANPSR1HTT | |
| SCHEMBL7456040 | 0.77 | ALDH1A1 (0.60) | ALDH1A1MAPTLMNANPSR1HTT | |
| SCHEMBL6666397 | 0.73 | CA1 (0.47) | ALDH1A1MAPTLMNANPSR1HPGD | |
| SCHEMBL6670734 | 0.71 | NPSR1 (0.35) | ALDH1A1MAPTLMNANPSR1HTT | |
| SCHEMBL7455884 | 0.70 | EHMT2 (0.45) | ALDH1A1MAPTLMNAHPGDMEN1 | |
| SCHEMBL2817703 | 0.69 | JUN (0.69) | ALDH1A1MAPTLMNAHPGDCCNC | |
| SCHEMBL2817704 | 0.69 | JUN (0.69) | ALDH1A1MAPTLMNAHPGDCCNC | |
| SCHEMBL5717702 | 0.69 | JUN (0.69) | ALDH1A1MAPTLMNAHPGDCCNC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1453828-A2 | AZABICYCLIC COMPOUNDS FOR THE TREATMENT OF FIBROMYALGIA SYNDROME | AstraZeneca AB (SE) | 2004-09-08 | — | — | EP | claimed |
| WO-2003032897-A2 | AZABICYCLIC COMPOUNDS FOR THE TREATMENT OF FIBROMYALGIA SYNDROME | ASTRAZENECA AB (SE) | 2003-04-24 | — | — | WO | claimed |
| EP-1235826-A1 | QUINUCLIDINE ACRYLAMIDES | AstraZeneca AB (SE) | 2002-09-04 | — | — | EP | claimed |
| WO-2001029034-A1 | QUINUCLIDINE ACRYLAMIDES | ASTRAZENECA AB (SE) | 2001-04-26 | — | — | WO | claimed |