SCHEMBL6665023

SCHEMBL6665023

CCc1ccc(C(F)(F)OC(C)c2ccc(C#N)c(F)c2)cc1

nearest known ligand 0.38

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
CYP11B1 P15538 7/20 0.38
CYP11B2 P19099 7/20 0.38
TRPV4 Q9HBA0 1/20 0.36
CACNA1H O95180 4/20 0.33
AR P10275 3/20 0.33
CYP2A6 P11509 1/20 0.33
TRPA1 O75762 1/20 0.32
DAO P14920 1/20 0.32
RORC P51449 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6661249 0.91 KDM4E (0.38) CYP11B1CYP11B2TRPV4CACNA1HAR
SCHEMBL6666058 0.88 TSHR (0.36) CYP11B1CYP11B2TRPV4CACNA1HAR
SCHEMBL6663195 0.85 CYP2A6 (0.34) TRPV4CYP2A6
SCHEMBL6664134 0.85 ALDH1A1 (0.35)
SCHEMBL6663001 0.82 ALDH1A1 (0.33)
SCHEMBL6667081 0.81 FFAR1 (0.38) DAO
SCHEMBL6661170 0.81 CYP2A6 (0.51) CYP2A6
SCHEMBL6666325 0.80 PDE2A (0.45) CACNA1H
SCHEMBL6661207 0.79 ALDH1A1 (0.36) CYP11B1CYP11B2AR
SCHEMBL6662051 0.79 CASR (0.34)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0893423-B1 LIQUID CRYSTAL COMPOUNDS HAVING FLUORINATED LINKAGES, LIQUID CRYSTAL COMPOSITIONS, AND LIQUID CRYSTAL DISPLAY DEVICES CHISSO CORP (JP) 2004-09-01 EP disclosed