SCHEMBL6661170

SCHEMBL6661170

CCc1ccc(C(F)(F)OC(C)c2ccc(C#N)cc2)cc1

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP2A6 P11509 1/20 0.51
KIF11 P52732 2/20 0.37
LOXL2 Q9Y4K0 2/20 0.35
CYP19A1 P11511 2/20 0.34
MAOA P21397 2/20 0.33
MAOB P27338 2/20 0.33
GRIA1 P42261 1/20 0.33
GRIA2 P42262 1/20 0.33
GRIA3 P42263 1/20 0.33
GRIA4 P48058 1/20 0.33
EPHX2 P34913 1/20 0.33
TSHR P16473 2/20 0.33
HSD17B10 Q99714 1/20 0.33
MLYCD O95822 1/20 0.32
ADRB2 P07550 1/20 0.32
ADRB1 P08588 1/20 0.32
ADRB3 P13945 1/20 0.32
PTPN5 P54829 1/20 0.32
MAPK1 P28482 1/20 0.32
ATM Q13315 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6665296 0.90 TSHR (0.40) CYP2A6KIF11LOXL2CYP19A1EPHX2
SCHEMBL6666751 0.86 HSD17B10 (0.52) CYP2A6KIF11CYP19A1TSHRHSD17B10
SCHEMBL6662033 0.84 ALDH1A1 (0.42) TSHRMAPK1ATMTDP1L3MBTL1
SCHEMBL6667003 0.83 LMNA (0.46) TSHRMAPK1ATMTDP1L3MBTL1
SCHEMBL6666034 0.82 TSHR (0.34) TSHRMAPK1ATMTDP1L3MBTL1
SCHEMBL6665023 0.81 CYP11B1 (0.38) CYP2A6
SCHEMBL6664947 0.81 PDE2A (0.44) EPHX2TSHRALDH1A1
SCHEMBL6663195 0.81 CYP2A6 (0.34) CYP2A6
SCHEMBL6666975 0.78 FAAH (0.43) HSD17B10ADRB3ALDH1A1LMNA
SCHEMBL6662930 0.78 PPARG (0.35) MAPK1L3MBTL1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0893423-B1 LIQUID CRYSTAL COMPOUNDS HAVING FLUORINATED LINKAGES, LIQUID CRYSTAL COMPOSITIONS, AND LIQUID CRYSTAL DISPLAY DEVICES CHISSO CORP (JP) 2004-09-01 EP disclosed