Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Pimagedine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.50 |
| ▸ | MAOA | P21397 | 1/20 | 0.50 |
| ▸ | MAOB | P27338 | 1/20 | 0.50 |
| ▸ | THPO | P40225 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 2/20 | 0.36 |
| ▸ | CA9 | Q16790 | 2/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | LDHA | P00338 | 1/20 | 0.35 |
| ▸ | LDHB | P07195 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | KDM5C | P41229 | 1/20 | 0.35 |
| ▸ | PHF8 | Q9UPP1 | 1/20 | 0.35 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pimagedine SCHEMBL27784772 | 1.00 | TSHR (0.50) | TSHRNFKB1CYP1A2MAOAMAOB | |
| Pimagedine SCHEMBL9952232 | 1.00 | TSHR (0.50) | TSHRNFKB1CYP1A2MAOAMAOB | |
| Pimagedine SCHEMBL40128 | 1.00 | — | — | |
| Pimagedine SCHEMBL28272894 | 0.97 | TSHR (0.47) | TSHRNFKB1CYP1A2MAOAMAOB | |
| Pimagedine SCHEMBL3279095 | 0.97 | LMNA (0.53) | TSHRNFKB1CYP1A2MAOAMAOB | |
| Oxalic Acid SCHEMBL507710 | 0.90 | TSHR (0.47) | TSHRNFKB1CYP1A2MAOAMAOB | |
| Oxalic Acid SCHEMBL507712 | 0.90 | TSHR (0.47) | TSHRNFKB1CYP1A2MAOAMAOB | |
| Pimagedine SCHEMBL1640210 | 0.89 | — | — | |
| Pimagedine SCHEMBL27920035 | 0.88 | CYP1A2 (0.40) | TSHRNFKB1CYP1A2MAOAMAOB | |
| Oxalic Acid SCHEMBL4946423 | 0.87 | TSHR (0.44) | TSHRNFKB1CYP1A2MAOAMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0844243-B1 | Sulfonamide compound and method for its production, metal chelate compound employing the sulfonamide compound, and optical recording medium employing the metal chelate compound | MITSUBISHI CHEM CORP (JP) | 2004-08-25 | — | — | EP | disclosed |
| US-6284877-B1 | Sulfonamide compound and method for its production, metal chelate compound employing the sulfonamide compound, and optical recording medium employing the metal chelate compound | MITSUBISHI CHEMICAL CORPORATION (JP) | 2001-09-04 | — | — | US | disclosed |
| US-6225023-B1 | INTERMEDIATE USEFUL FOR THE SYNTHESIS OF AZO DYE, DESIGNED TO USE SEMICONDUCTOR LASER OF SHORT WAVELENGTH. | MITSUBISHI CHEMICAL CORPORATION (JP) | 2001-05-01 | — | — | US | disclosed |
| EP-0844243-A1 | Sulfonamide compound and method for its production, metal chelate compound employing the sulfonamide compound, and optical recording medium employing the metal chelate compound | MITSUBISHI CHEMICAL CORPORATION (JP) | 1998-05-27 | — | — | EP | disclosed |