Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GNRHR | P30968 | 2/20 | 0.47 |
| ▸ | FPR1 | P21462 | 1/20 | 0.47 |
| ▸ | GPR183 | P32249 | 1/20 | 0.47 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.47 |
| ▸ | S1PR4 | O95977 | 5/20 | 0.42 |
| ▸ | MDH1 | P40925 | 3/20 | 0.40 |
| ▸ | MDH2 | P40926 | 3/20 | 0.40 |
| ▸ | S1PR2 | O95136 | 3/20 | 0.39 |
| ▸ | S1PR5 | Q9H228 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | ACAT1 | P24752 | 1/20 | 0.36 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.36 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6666402 | 0.91 | S1PR4 (0.44) | GNRHRFPR1GPR183GPR119S1PR4 | |
| SCHEMBL4861853 | 0.90 | GNRHR (0.47) | GNRHRFPR1GPR183GPR119S1PR4 | |
| SCHEMBL6669190 | 0.88 | GNRHR (0.47) | GNRHRFPR1GPR183GPR119S1PR4 | |
| SCHEMBL6639154 | 0.85 | GNRHR (0.47) | GNRHRFPR1GPR183GPR119S1PR4 | |
| SCHEMBL4862829 | 0.83 | GNRHR (0.46) | GNRHRFPR1GPR183GPR119S1PR4 | |
| SCHEMBL4852148 | 0.83 | GNRHR (0.46) | GNRHRFPR1GPR183GPR119S1PR4 | |
| SCHEMBL6645028 | 0.82 | FPR1 (0.48) | GNRHRFPR1GPR183GPR119S1PR4 | |
| SCHEMBL4863755 | 0.81 | GNRHR (0.48) | GNRHRFPR1GPR183GPR119S1PR4 | |
| SCHEMBL6669991 | 0.81 | GNRHR (0.48) | GNRHRFPR1GPR183GPR119S1PR4 | |
| SCHEMBL14395680 | 0.80 | GNRHR (0.47) | GNRHRFPR1GPR183GPR119S1PR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1401427-A4 | NON-PEPTIDE GNRH AGENTS, PHARMACEUTICAL COMPOSITIONS AND METHODS FOR THEIR USES, AND PROCESSES FOR PREPARING THEM | AGOURON PHARMA (US) | 2004-12-01 | — | — | EP | disclosed |
| EP-1401427-A2 | NON-PEPTIDE GNRH AGENTS, PHARMACEUTICAL COMPOSITIONS AND METHODS FOR THEIR USES, AND PROCESSES FOR PREPARING THEM | Agouron Pharmaceuticals, Inc. (US) | 2004-03-31 | — | — | EP | disclosed |
| WO-2002098363-A2 | NON-PEPTIDE GnRH AGENTS, PHARMACEUTICAL COMPOSITIONS AND METHODS FOR THEIR USES, AND PROCESSES FOR PREPARING THEM | AGOURON PHARMACEUTICALS, INC. (US) | 2002-12-12 | — | — | WO | disclosed |