Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 6/20 | 0.50 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | HTR2C | P28335 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | HTR2B | P41595 | 1/20 | 0.42 |
| ▸ | MTOR | P42345 | 1/20 | 0.42 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31510089 | 0.86 | KDM1A (0.48) | KDM1ATSHRSIGMAR1TP53CYP1A2 | |
| SCHEMBL11254662 | 0.86 | KDM1A (0.48) | KDM1ATSHRSIGMAR1TP53CYP1A2 | |
| SCHEMBL31052615 | 0.76 | SIGMAR1 (0.60) | TSHRMEN1KMT2ASIGMAR1TP53 | |
| SCHEMBL18192167 | 0.76 | SIGMAR1 (0.60) | TSHRMEN1KMT2ASIGMAR1TP53 | |
| SCHEMBL31277604 | 0.75 | KDM1A (0.57) | KDM1AAKR1B1CYP3A4 | |
| SCHEMBL3699642 | 0.75 | KDM1A (0.57) | KDM1AAKR1B1CYP3A4 | |
| SCHEMBL578812 | 0.74 | KDM1A (0.59) | KDM1AAKR1B1TSHRMEN1KMT2A | |
| SCHEMBL11704179 | 0.74 | SIGMAR1 (0.58) | TSHRMEN1KMT2ASIGMAR1TP53 | |
| SCHEMBL4195493 | 0.74 | KDM1A (0.50) | KDM1AAKR1B1TSHRMEN1KMT2A | |
| SCHEMBL1101137 | 0.74 | KDM1A (0.59) | KDM1AAKR1B1TSHRMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4729508-A1 | TETRALIN AND TETRAHYDROQUINOLINE COMPOUNDS AS INHIBITORS OF HIF-2ALPHA | Arcus Biosciences, Inc. (US) | 2026-04-22 | — | — | EP | disclosed |
| US-20250214930-A1 | TETRALIN AND TETRAHYDROQUINOLINE COMPOUNDS AS INHIBITORS OF HIF-2ALPHA | ARCUS BIOSCIENCES, INC. (US) | 2025-07-03 | — | — | US | disclosed |
| US-12162888-B2 | Carboxamides as ubiquitin-specific protease inhibitors | VALO HEALTH, INC. (US) | 2024-12-10 | — | — | US | disclosed |
| US-12103907-B2 | Tetralin and tetrahydroquinoline compounds as inhibitors of HIF-2alpha | ARCUS BIOSCIENCES, INC. (US) | 2024-10-01 | — | — | US | disclosed |
| US-20240254079-A1 | TETRALIN AND TETRAHYDROQUINOLINE COMPOUNDS AS INHIBITORS OF HIF-2ALPHA | ARCUS BIOSCIENCES, INC. | 2024-08-01 | — | — | US | disclosed |
| US-11787762-B2 | Tetralin and tetrahydroquinoline compounds as inhibitors of HIF-2alpha | ARCUS BIOSCIENCES, INC. (US) | 2023-10-17 | — | — | US | disclosed |
| US-20230021476-A1 | TETRALIN AND TETRAHYDROQUINOLINE COMPOUNDS AS INHIBITORS OF HIF-2ALPHA | ARCUS BIOSCIENCES, INC. | 2023-01-26 | — | — | US | disclosed |
| EP-4121409-A1 | TETRALIN AND TETRAHYDROQUINOLINE COMPOUNDS AS INHIBITORS OF HIF-2ALPHA | Arcus Biosciences, Inc. (US) | 2023-01-25 | — | — | EP | disclosed |
| CN-115298165-A | Tetralin and tetrahydroquinoline compounds as HIF-2 alpha inhibitors | 艾库斯生物科学有限公司 | 2022-11-04 | — | — | CN | disclosed |
| US-11407712-B2 | Tetralin and tetrahydroquinoline compounds as inhibitors of HIF-2α | ARCUS BIOSCIENCES, INC. (US) | 2022-08-09 | — | — | US | disclosed |
| US-20210317079-A1 | TETRALIN AND TETRAHYDROQUINOLINE COMPOUNDS AS INHIBITORS OF HIF-2ALPHA | ARCUS BIOSCIENCES, INC. | 2021-10-14 | — | — | US | disclosed |
| WO-2021188769-A1 | TETRALIN AND TETRAHYDROQUINOLINE COMPOUNDS AS INHIBITORS OF HIF-2ALPHA | ARCUS BIOSCIENCES, INC. (US) | 2021-09-23 | — | — | WO | disclosed |
| CN-106699532-A | Preparing method of 1,1-difluoro tetrahydronaphthalene compound | 浙江师范大学 | 2017-05-24 | — | — | CN | disclosed |
| CN-106699532-A | Preparing method of 1,1-difluoro tetrahydronaphthalene compound | 浙江师范大学 | 2017-05-24 | — | — | CN | disclosed |
| CN-102992972-B | Liquid crystal compound and preparation and application thereof | BEIJING BAYI SPACE LCD MATERIALS TECHNOLOGY CO LTD | 2015-01-07 | — | — | CN | disclosed |
| CN-102992972-B | Liquid crystal compound and preparation and application thereof | BEIJING BAYI SPACE LCD MATERIALS TECHNOLOGY CO LTD | 2015-01-07 | — | — | CN | disclosed |
| CN-102888227-B | Liquid crystal compound and preparation method and application thereof | BEIJING BAYI SPACE LCD MATERIALS TECHNOLOGY CO LTD | 2014-11-26 | — | — | CN | disclosed |
| CN-102992972-A | Liquid crystal compound and preparation and application thereof | BEIJING BAYI SPACE LCD MATERIALS TECHNOLOGY CO LTD | 2013-03-27 | — | — | CN | disclosed |
| JP-2004352931-A | LIQUID CRYSTAL COMPOSITION CONTAINING DIFLUOROTETRAHYDRONAPHTHALENE DERIVATIVE AND LIQUID CRYSTALLINE COMPOUND | DAINIPPON INK & CHEM INC | 2004-12-16 | — | — | JP | disclosed |
| JP-2002284722-A | METHOD FOR PRODUCING 5,6,7-TRIFLUORO-1,2,3,4- TETRAHYDRONAPHTHALENE DERIVATIVE | DAINIPPON INK & CHEM INC | 2002-10-03 | — | — | JP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250214930-A1 | TETRALIN AND TETRAHYDROQUINOLINE COMPOUNDS AS INHIBITORS OF HIF-2ALPHA | HIF1AN, HIF1A, EGLN2 | KDM1A 1192/4885AKR1B1 2282/4885TSHR 3265/4885 |
| US-20240254079-A1 | TETRALIN AND TETRAHYDROQUINOLINE COMPOUNDS AS INHIBITORS OF HIF-2ALPHA | HIF1AN, HIF1A, EGLN2 | KDM1A 1192/4885AKR1B1 2282/4885TSHR 3265/4885 |
| US-11787762-B2 | Tetralin and tetrahydroquinoline compounds as inhibitors of HIF-2alpha | HIF1AN, HIF1A, EGLN2 | KDM1A 1192/4885AKR1B1 2282/4885TSHR 3265/4885 |
| US-20230021476-A1 | TETRALIN AND TETRAHYDROQUINOLINE COMPOUNDS AS INHIBITORS OF HIF-2ALPHA | HIF1AN, HIF1A, EGLN2 | KDM1A 1192/4885AKR1B1 2282/4885TSHR 3265/4885 |
| US-11407712-B2 | Tetralin and tetrahydroquinoline compounds as inhibitors of HIF-2α | HIF1AN, HIF1A, EGLN2 | KDM1A 1155/4885AKR1B1 2301/4885TSHR 3118/4885 |
| US-12162888-B2 | Carboxamides as ubiquitin-specific protease inhibitors | USP28, USP25, USP24 | KDM1A 153/4885AKR1B1 3623/4885TSHR 4209/4885 |
| US-12103907-B2 | Tetralin and tetrahydroquinoline compounds as inhibitors of HIF-2alpha | HIF1AN, HIF1A, EGLN2 | KDM1A 1192/4885AKR1B1 2282/4885TSHR 3265/4885 |
| US-20210317079-A1 | TETRALIN AND TETRAHYDROQUINOLINE COMPOUNDS AS INHIBITORS OF HIF-2ALPHA | HIF1AN, HIF1A, EGLN2 | KDM1A 1192/4885AKR1B1 2282/4885TSHR 3265/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.