SCHEMBL6669062

SCHEMBL6669062

COC(=O)c1cccc(COC(=O)c2ccccc2)c1

nearest known ligand 0.75

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RAB9A P51151 5/20 0.75
MAPT P10636 4/20 0.75
ALDH1A1 P00352 3/20 0.75
SMN1; SMN2 Q16637 3/20 0.75
KDM4E B2RXH2 2/20 0.75
SLC6A2 P23975 1/20 0.67
SLC6A3 Q01959 1/20 0.67
KMT2A Q03164 1/20 0.67
TDP1 Q9NUW8 1/20 0.67
LOXL2 Q9Y4K0 1/20 0.62
CYP4F2 P78329 2/20 0.60
CYP4A11 Q02928 2/20 0.60
TSHR P16473 3/20 0.59
HPGD P15428 1/20 0.59
NPSR1 Q6W5P4 1/20 0.59
NPC1 O15118 3/20 0.58
SLC7A5 Q01650 1/20 0.57
MRGPRX4 Q96LA9 2/20 0.57
LMNA P02545 1/20 0.57
HIF1A Q16665 1/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27337757 0.92 KMT2A (0.69) RAB9AMAPTALDH1A1SMN1; SMN2KDM4E
SCHEMBL21171359 0.90 MAPT (0.76) RAB9AMAPTALDH1A1SMN1; SMN2KDM4E
SCHEMBL20830625 0.88 TDP1 (0.67) RAB9AMAPTALDH1A1SMN1; SMN2KDM4E
SCHEMBL22388846 0.87 KMT2A (0.76) RAB9AMAPTALDH1A1SMN1; SMN2KDM4E
SCHEMBL5085785 0.87 KMT2A (0.81) RAB9AMAPTALDH1A1SMN1; SMN2KDM4E
SCHEMBL6667451 0.86 LOXL2 (0.64) RAB9AMAPTALDH1A1SMN1; SMN2KDM4E
4-Methylbenzoic Acid Methyl Ester SCHEMBL7946632 0.85 MAPT (0.64) RAB9AMAPTALDH1A1SMN1; SMN2KDM4E
SCHEMBL13469247 0.84 TDP1 (0.71) RAB9AMAPTALDH1A1SMN1; SMN2KDM4E
SCHEMBL23746479 0.84 MAPT (0.66) RAB9AMAPTALDH1A1SMN1; SMN2KDM4E
SCHEMBL31455827 0.84 RAB9A (0.61) RAB9AMAPTALDH1A1SMN1; SMN2KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1004621-B1 GAMMA-RAY STABILIZER AND THERMOPLASTIC POLYMER COMPOSITION CONTAINING THE SAME TEIJIN CHEMICALS LTD (JP) 2004-09-15 EP disclosed
US-6485657-B1 Gamma-ray stabilizer and thermoplastic polymer compound including the said stabilizer TEIJIN, LIMITED (JP) 2002-11-26 US disclosed
EP-1004621-A1 GAMMA-RAY STABILIZER AND THERMOPLASTIC POLYMER COMPOSITION CONTAINING THE SAME TEIJIN LIMITED (JP) 2000-05-31 EP disclosed