Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 9/20 | 0.45 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.41 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.41 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.41 |
| ▸ | PDE4A | P27815 | 1/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.41 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6666169 | 0.95 | KCNH2 (0.49) | KCNH2 | |
| SCHEMBL14573143 | 0.84 | KCNH2 (0.55) | KCNH2MCHR1 | |
| SCHEMBL6669043 | 0.84 | KCNH2 (0.54) | KCNH2 | |
| SCHEMBL6664492 | 0.83 | KCNH2 (0.41) | KCNH2 | |
| SCHEMBL6669764 | 0.81 | ALDH1A1 (0.50) | KCNH2 | |
| SCHEMBL5764668 | 0.80 | KCNH2 (0.53) | KCNH2MCHR1 | |
| SCHEMBL14573144 | 0.80 | KCNH2 (0.61) | KCNH2 | |
| SCHEMBL3250060 | 0.79 | KCNH2 (0.62) | KCNH2 | |
| SCHEMBL5656040 | 0.78 | MEN1 (0.53) | ADRA1DADRA1AADRA1B | |
| SCHEMBL5777234 | 0.77 | KCNH2 (0.52) | KCNH2MCHR1ADRA1DADRA1AADRA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1392686-A1 | BICYCLIC NITROGEN-CONTAINING HETEROCYCLIC DERIVATIVES FOR USE AS ANTIBACTERIALS | SMITHKLINE BEECHAM PLC (GB) | 2004-03-03 | — | — | EP | claimed |
| WO-2002096907-A1 | BICYCLIC NITROGEN-CONTAINING HETEROCYCLIC DERIVATIVES FOR USE AS ANTIBACTERIALS | SMITHKLINE BEECHAM P.L.C. (GB) | 2002-12-05 | — | — | WO | claimed |