Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | LMNA | P02545 | 4/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 7/20 | 0.44 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6666169 | 0.86 | KCNH2 (0.49) | KCNH2 | |
| SCHEMBL14573155 | 0.84 | KCNH2 (0.61) | ALDH1A1LMNASMN1; SMN2KDM4ENPC1 | |
| SCHEMBL6669043 | 0.82 | KCNH2 (0.54) | KCNH2 | |
| SCHEMBL6667458 | 0.81 | KCNH2 (0.45) | KCNH2 | |
| SCHEMBL5762645 | 0.80 | KCNH2 (0.53) | ALDH1A1LMNASMN1; SMN2KDM4ENPC1 | |
| SCHEMBL5655879 | 0.78 | LMNA (0.74) | ALDH1A1LMNASMN1; SMN2KDM4ENPC1 | |
| SCHEMBL6669762 | 0.74 | ALDH1A1 (0.40) | ALDH1A1LMNASMN1; SMN2KDM4ENPC1 | |
| SCHEMBL6664492 | 0.71 | KCNH2 (0.41) | KCNH2 | |
| SCHEMBL3250060 | 0.70 | KCNH2 (0.62) | KCNH2SLC2A1 | |
| SCHEMBL14573144 | 0.70 | KCNH2 (0.61) | KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1392686-A1 | BICYCLIC NITROGEN-CONTAINING HETEROCYCLIC DERIVATIVES FOR USE AS ANTIBACTERIALS | SMITHKLINE BEECHAM PLC (GB) | 2004-03-03 | — | — | EP | claimed |
| WO-2002096907-A1 | BICYCLIC NITROGEN-CONTAINING HETEROCYCLIC DERIVATIVES FOR USE AS ANTIBACTERIALS | SMITHKLINE BEECHAM P.L.C. (GB) | 2002-12-05 | — | — | WO | claimed |