⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1031474 | 1.00 | — | — | |
| SCHEMBL1032112 | 1.00 | — | — | |
| SCHEMBL20599481 | 0.81 | TP53 (0.40) | — | |
| SCHEMBL11358364 | 0.79 | TP53 (0.38) | — | |
| SCHEMBL715386 | 0.78 | TP53 (0.57) | — | |
| SCHEMBL83830 | 0.78 | TP53 (0.57) | — | |
| SCHEMBL812149 | 0.78 | TP53 (0.57) | — | |
| SCHEMBL13310465 | 0.78 | TP53 (0.57) | — | |
| SCHEMBL812166 | 0.78 | TP53 (0.57) | — | |
| SCHEMBL1031473 | 0.76 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 43 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3397627-A1 | INDOLIZINE DERIVATIVES, COMPOSITION AND METHODS OF USE | Shanghai Fochon Pharmaceutical Co., Ltd. (CN) | 2018-11-07 | — | — | EP | claimed |
| WO-2017121308-A1 | FUSED PYRIDINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE | Chongqing Fochon Pharmaceutical Co., Ltd. (CN) | 2017-07-20 | — | — | WO | claimed |
| WO-2017114352-A1 | INDOLIZINE DERIVATIVES, COMPOSITION AND METHODS OF USE | Chongqing Fochon Pharmaceutical Co., Ltd. (CN) | 2017-07-06 | — | — | WO | claimed |
| CN-119285572-A | Kinase inhibitors and uses thereof | 戴纳立制药公司 | 2025-01-10 | — | — | CN | disclosed |
| CN-119264073-A | Kinase inhibitors and uses thereof | 戴纳立制药公司 | 2025-01-07 | — | — | CN | disclosed |
| CN-110913858-B | Kinase inhibitors and uses thereof | 戴纳立制药公司 | 2024-09-24 | — | — | CN | disclosed |
| CN-108602809-B | Isoxazolidine derived inhibitors of receptor interacting protein kinase 1(RIPK 1) | 戴纳立制药公司 | 2022-09-30 | — | — | CN | disclosed |
| CN-115073265-A | Preparation method of 2, 2-difluoropropanol | 南通华祥医药科技有限公司 | 2022-09-20 | — | — | CN | disclosed |
| US-10709692-B2 | Isoxazolidine derived inhibitors of receptor interacting protein kinase 1 (RIPK1) | DENALI THERAPEUTICS INC. (US) | 2020-07-14 | — | — | US | disclosed |
| US-20180353480-A1 | ISOXAZOLIDINE DERIVED INHIBITORS OF RECEPTOR INTERACTING PROTEIN KINASE 1 (RIPK1) | APTUIT (VERONA) S.R.L. (IT) | 2018-12-13 | — | — | US | disclosed |
| EP-3397627-A1 | INDOLIZINE DERIVATIVES, COMPOSITION AND METHODS OF USE | Shanghai Fochon Pharmaceutical Co., Ltd. (CN) | 2018-11-07 | — | — | EP | disclosed |
| CN-1244865-A | Substituted pyrazole-3-yl benzazoles | BASF AK (DE) | 2000-02-16 | — | — | CN | disclosed |
| WO-1999055702-A1 | SUBSTITUTED (4-BROMPYRAZOLE-3-YL)BENZAZOLES | BASF AKTIENGESELLSCHAFT (DE) | 1999-11-04 | — | — | WO | disclosed |
| EP-0944623-A2 | SUBSTITUTED PYRAZOLE-3-YL BENZAZOLES | BASF AKTIENGESELLSCHAFT (DE) | 1999-09-29 | — | — | EP | disclosed |
| CN-1189824-A | 1-amino-3-benzyluracils | BASF AG (DE) | 1998-08-05 | — | — | CN | disclosed |
| WO-1998027090-A2 | SUBSTITUTED PYRAZOLE-3-YL BENZAZOLES | BASF AKTIENGESELLSCHAFT (DE) | 1998-06-25 | — | — | WO | disclosed |
| EP-0024965-B1 | FLUORINATED METHYL BETA-ALANINE DERIVATIVES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | MERRELL TORAUDE ET COMPAGNIE (FR) | 1983-04-27 | — | — | EP | disclosed |
| US-4375477-A | ENZYME INHIBITORS | MERRELL TORAUDE ET COMPAGNIE (FR) | 1983-03-01 | — | — | US | disclosed |
| EP-0024965-A1 | Fluorinated methyl beta-alanine derivatives, their preparation and pharmaceutical compositions containing them | MERRELL TORAUDE ET COMPAGNIE (FR) | 1981-03-11 | — | — | EP | disclosed |
| US-4139594-A | IN THE PRESENCE OF AN ALKANOIC ACID AND A NON-ACIDIC SOLVENT | HALCON RESEARCH & DEVELOPMENT CORP. (US) | 1979-02-13 | — | — | US | disclosed |