Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.57 |
| ▸ | SLC7A5 | Q01650 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.39 |
| ▸ | LCK | P06239 | 1/20 | 0.39 |
| ▸ | FYN | P06241 | 1/20 | 0.39 |
| ▸ | GABRR1 | P24046 | 2/20 | 0.38 |
| ▸ | RNPEP | Q9H4A4 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL812149 | 1.00 | TP53 (0.57) | TP53SLC7A5TSHRLMNAALDH1A1 | |
| SCHEMBL715386 | 1.00 | TP53 (0.57) | TP53SLC7A5TSHRLMNAALDH1A1 | |
| SCHEMBL83830 | 1.00 | TP53 (0.57) | TP53SLC7A5TSHRLMNAALDH1A1 | |
| SCHEMBL13310465 | 1.00 | TP53 (0.57) | TP53SLC7A5TSHRLMNAALDH1A1 | |
| SCHEMBL6735445 | 0.96 | TP53 (0.53) | TP53SLC7A5TSHRLMNAALDH1A1 | |
| SCHEMBL11445671 | 0.96 | TP53 (0.53) | TP53SLC7A5TSHRLMNAALDH1A1 | |
| SCHEMBL11445718 | 0.96 | TP53 (0.53) | TP53SLC7A5TSHRLMNAALDH1A1 | |
| SCHEMBL9635648 | 0.89 | TP53 (0.47) | TP53SLC7A5TSHRLMNAALDH1A1 | |
| SCHEMBL25575130 | 0.86 | TP53 (0.44) | TP53SLC7A5TSHRALDH1A1FFAR3 | |
| SCHEMBL10570748 | 0.86 | TP53 (0.44) | TP53SLC7A5TSHRALDH1A1FFAR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230357347-A1 | MODULATORS OF G-PROTEIN COUPLED RECEPTORS | CARMOT THERAPEUTICS, INC. | 2023-11-09 | — | — | US | disclosed |
| US-11718586-B2 | Method for preparing dexmedetomidine | NORCHIM (FR) | 2023-08-08 | — | — | US | disclosed |
| US-8962858-B2 | Methods and compounds useful in the synthesis of fused aminodihydrothiazine derivatives | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2015-02-24 | — | — | US | disclosed |
| US-20140309429-A1 | METHODS AND COMPOUNDS USEFUL IN THE SYNTHESIS OF FUSED AMINODIHYDROTHIAZINE DERIVATIVES | EISAI R&D MAN CO LTD (JP) | 2014-10-16 | — | — | US | disclosed |
| US-8802871-B2 | Methods and compounds useful in the synthesis of fused aminodihydrothiazine derivatives | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2014-08-12 | — | — | US | disclosed |
| US-20130197244-A1 | METHODS AND COMPOUNDS USEFUL IN THE SYNTHESIS OF FUSED AMINODIHYDROTHIAZINE DERIVATIVES | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2013-08-01 | — | — | US | disclosed |
| US-8426584-B2 | Methods and compounds useful in the synthesis of fused aminodihydrothiazine derivatives | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2013-04-23 | — | — | US | disclosed |
| US-20120190848-A1 | METHODS AND COMPOUNDS USEFUL IN THE SYNTHESIS OF FUSED AMINODIHYDROTHIAZINE DERIVATIVES | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2012-07-26 | — | — | US | disclosed |
| US-7906676-B2 | Process for preparing 3-amino-5-fluoro-4-dialkoxypentanoic acid ester | LG LIFE SCIENCES LTD. (KR) | 2011-03-15 | — | — | US | disclosed |
| US-7781427-B2 | Process for preparing quinoline compounds and products obtained therefrom | WYETH LLC (US) | 2010-08-24 | — | — | US | disclosed |
| US-7572916-B2 | Diastereoselective synthesis process with 6-bromo-4-(3-chlorophenyl)-2-methoxy-quinoline | JANSSEN PHARMACEUTICA NV (BE) | 2009-08-11 | — | — | US | disclosed |
| US-7524961-B2 | Diastereoselective addition of lithiated N-methylimidazole on sulfinimines | JANSSEN PHARMACEUTICA, N.V. (BE) | 2009-04-28 | — | — | US | disclosed |
| US-7456287-B2 | Diastereoselective synthesis process for the preparation of imidazole compounds | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-11-25 | — | — | US | disclosed |
| US-20070293679-A1 | Diastereoselective Addition of Lithiated N-Methylimidazole on Sulfinimines | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-12-20 | — | — | US | disclosed |
| US-20070293680-A1 | For the preparation of (R)-(+)-6-[amino(4-chlorophenyl)(1-methyl-1H-imidazol-5-yl) methyl]-4-(3-chlorophenyl)-1-methyl2(1H)-quinolinone; farnesyl tranferase inhibitory activity | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-12-20 | — | — | US | disclosed |
| US-20070238880-A1 | Diastereoselective Synthesis Process for the Preparation of Imidazole Compounds | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-10-11 | — | — | US | disclosed |
| US-20070197604-A1 | Oxazole derivatives as histamine h3 receptor agents,preparation and therapeutic uses | ELI LILLY AND COMPANY | 2007-08-23 | — | — | US | disclosed |
| US-20070197604-A1 | Oxazole derivatives as histamine h3 receptor agents,preparation and therapeutic uses | ELI LILLY AND COMPANY | 2007-08-23 | — | — | US | disclosed |
| EP-0561758-A2 | Method of preparing optically active homo-beta-amino acids | MONSANTO COMPANY (US) | 1993-09-22 | — | — | EP | disclosed |
| EP-0341713-A2 | Optically active compounds, liquid crystal compositions comprising said compounds, and liquid crystal optical modulators using said compositions | HITACHI, LTD. (JP) | 1989-11-15 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230357347-A1 | MODULATORS OF G-PROTEIN COUPLED RECEPTORS | GIPR, GLP1R, GCGR | TP53 2664/4885SLC7A5 2798/4885TSHR 140/4885 |
| US-11718586-B2 | Method for preparing dexmedetomidine | ADH1C, ADH1A, ADH5 | TP53 4869/4885SLC7A5 4001/4885TSHR 708/4885 |
| US-20070197604-A1 | Oxazole derivatives as histamine h3 receptor agents,preparation and therapeutic uses | HCRTR1, HRH3, HCRTR2 | TP53 4782/4885SLC7A5 1926/4885TSHR 222/4885 |
| US-20140309429-A1 | METHODS AND COMPOUNDS USEFUL IN THE SYNTHESIS OF FUSED AMINODIHYDROTHIAZINE DERIVATIVES | APP, BACE1, BACE2 | TP53 877/4885SLC7A5 510/4885TSHR 4545/4885 |
| US-20070293680-A1 | For the preparation of (R)-(+)-6-[amino(4-chlorophenyl)(1-methyl-1H-imidazol-5-yl) methyl]-4-(3-chlorophenyl)-1-methyl2(1H)-quinolinone; farnesyl tranferase inhibitory activity | FNTB, CYP4F2, FNTA | TP53 4507/4885SLC7A5 1047/4885TSHR 2131/4885 |
| US-20130197244-A1 | METHODS AND COMPOUNDS USEFUL IN THE SYNTHESIS OF FUSED AMINODIHYDROTHIAZINE DERIVATIVES | APP, BACE1, BACE2 | TP53 877/4885SLC7A5 510/4885TSHR 4545/4885 |
| US-20070238880-A1 | Diastereoselective Synthesis Process for the Preparation of Imidazole Compounds | DHPS, CYP2S1, CYP1A2 | TP53 4389/4885SLC7A5 1434/4885TSHR 3963/4885 |
| US-20070293679-A1 | Diastereoselective Addition of Lithiated N-Methylimidazole on Sulfinimines | SULT1A1, SULT1E1, CSNK1A1L | TP53 4067/4885SLC7A5 1855/4885TSHR 3785/4885 |
| US-20120190848-A1 | METHODS AND COMPOUNDS USEFUL IN THE SYNTHESIS OF FUSED AMINODIHYDROTHIAZINE DERIVATIVES | APP, BACE1, BACE2 | TP53 877/4885SLC7A5 510/4885TSHR 4545/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.