Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.46 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.40 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.40 |
| ▸ | CES2 | O00748 | 1/20 | 0.40 |
| ▸ | CES1 | P23141 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.39 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.39 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.39 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.38 |
| ▸ | CASP3 | P42574 | 1/20 | 0.38 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.38 |
| ▸ | UGT2B7 | P16662 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6672136 | 0.83 | HDAC8 (0.49) | HDAC8CDK5CDK5R1CES2CES1 | |
| SCHEMBL6669961 | 0.80 | HDAC8 (0.47) | HDAC8CES2CES1SMN1; SMN2KDM4E | |
| SCHEMBL7440698 | 0.77 | GAA (0.53) | HDAC8CES2CES1SMN1; SMN2KDM4E | |
| SCHEMBL7440691 | 0.77 | GAA (0.53) | HDAC8CES2CES1SMN1; SMN2KDM4E | |
| SCHEMBL6667377 | 0.75 | HDAC8 (0.54) | HDAC8CES2CES1SMN1; SMN2KDM4E | |
| SCHEMBL6672244 | 0.75 | GRIN1 (0.46) | HDAC8CES2CES1SMN1; SMN2KDM4E | |
| SCHEMBL28958988 | 0.69 | HDAC8 (0.54) | HDAC8CES2CES1SMN1; SMN2KDM4E | |
| SCHEMBL30421947 | 0.69 | HDAC8 (0.54) | HDAC8CES2CES1SMN1; SMN2KDM4E | |
| SCHEMBL14118638 | 0.69 | HRH3 (0.56) | CES2CES1SMN1; SMN2KDM4EHPGD | |
| SCHEMBL28341243 | 0.68 | HDAC8 (0.47) | HDAC8CES2CES1SMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1133467-B1 | ION CHANNEL MODULATING AGENTS | NEUROSEARCH AS (DK) | 2004-09-15 | — | — | EP | claimed |
| US-20040248099-A1 | Use of intermediate -conductance potassium channels and modulators for diagnosing and treating diseases having disturbed keratinocyte activity | SWITCH BIOTECH AKTIENGESELLSCHAFT (DE) | 2004-12-09 | — | — | US | disclosed |