Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.49 |
| ▸ | CES2 | O00748 | 1/20 | 0.43 |
| ▸ | CES1 | P23141 | 1/20 | 0.43 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.43 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.43 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.42 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.41 |
| ▸ | F2 | P00734 | 1/20 | 0.41 |
| ▸ | PLG | P00747 | 1/20 | 0.41 |
| ▸ | PLAU | P00749 | 1/20 | 0.41 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.41 |
| ▸ | KLK1 | P06870 | 1/20 | 0.41 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6669961 | 0.84 | HDAC8 (0.47) | HDAC8CES2CES1GRIN1GRIN2B | |
| SCHEMBL6667919 | 0.83 | HDAC8 (0.46) | HDAC8CES2CES1GRIN1GRIN2B | |
| SCHEMBL6666528 | 0.81 | PPARG (0.42) | CES2CES1GRIN1GRIN2BSMN1; SMN2 | |
| SCHEMBL7440691 | 0.81 | GAA (0.53) | HDAC8CES2CES1GRIN1GRIN2B | |
| SCHEMBL7440698 | 0.81 | GAA (0.53) | HDAC8CES2CES1GRIN1GRIN2B | |
| SCHEMBL6667377 | 0.79 | HDAC8 (0.54) | HDAC8CES2CES1GRIN1GRIN2B | |
| SCHEMBL6672244 | 0.78 | GRIN1 (0.46) | HDAC8CES2CES1GRIN1GRIN2B | |
| SCHEMBL3966940 | 0.78 | ATM (0.47) | GAASMN1; SMN2MEN1KMT2AKDM4E | |
| SCHEMBL27209008 | 0.78 | ATM (0.47) | GAASMN1; SMN2MEN1KMT2AKDM4E | |
| SCHEMBL6906641 | 0.76 | PTPN1 (0.61) | HDAC8CES2CES1SMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1133467-B1 | ION CHANNEL MODULATING AGENTS | NEUROSEARCH AS (DK) | 2004-09-15 | — | — | EP | claimed |