Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.47 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | CES2 | O00748 | 1/20 | 0.41 |
| ▸ | CES1 | P23141 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.39 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | F2 | P00734 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6672136 | 0.84 | HDAC8 (0.49) | HDAC8PTGS1PTGS2NPC1RAB9A | |
| SCHEMBL6672244 | 0.82 | GRIN1 (0.46) | HDAC8NPC1SMN1; SMN2ALDH1A1CES2 | |
| SCHEMBL7440698 | 0.82 | GAA (0.53) | HDAC8PTGS1PTGS2NPC1RAB9A | |
| SCHEMBL7440691 | 0.82 | GAA (0.53) | HDAC8PTGS1PTGS2NPC1RAB9A | |
| SCHEMBL6667919 | 0.80 | HDAC8 (0.46) | HDAC8PTGS1PTGS2NPC1RAB9A | |
| SCHEMBL6667377 | 0.76 | HDAC8 (0.54) | HDAC8NPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL30421947 | 0.76 | HDAC8 (0.54) | HDAC8NPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL28958988 | 0.76 | HDAC8 (0.54) | HDAC8NPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL7831102 | 0.74 | HDAC8 (0.62) | HDAC8NPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL7831105 | 0.74 | HDAC8 (0.62) | HDAC8NPC1RAB9ASMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1133467-B1 | ION CHANNEL MODULATING AGENTS | NEUROSEARCH AS (DK) | 2004-09-15 | — | — | EP | claimed |
| US-20040248099-A1 | Use of intermediate -conductance potassium channels and modulators for diagnosing and treating diseases having disturbed keratinocyte activity | SWITCH BIOTECH AKTIENGESELLSCHAFT (DE) | 2004-12-09 | — | — | US | disclosed |