Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN1 | Q05586 | 2/20 | 0.46 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.46 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.45 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | PPARG | P37231 | 1/20 | 0.42 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.42 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.42 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | BDKRB2 | P30411 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9377338 | 0.82 | TSHR (0.50) | KMT2APOLBTSHRMAPTKDM4E | |
| SCHEMBL6669961 | 0.82 | HDAC8 (0.47) | GRIN1GRIN2BHDAC8KMT2AMEN1 | |
| SCHEMBL7908828 | 0.81 | NR4A1 (0.55) | KMT2AMEN1CYP1A2CYP2C19MAPT | |
| SCHEMBL6672136 | 0.78 | HDAC8 (0.49) | GRIN1GRIN2BHDAC8KMT2AMEN1 | |
| SCHEMBL6667919 | 0.75 | HDAC8 (0.46) | GRIN1GRIN2BHDAC8KDM4EALDH1A1 | |
| SCHEMBL6667377 | 0.74 | HDAC8 (0.54) | GRIN1GRIN2BHDAC8KMT2AMEN1 | |
| SCHEMBL29183337 | 0.73 | SMN1; SMN2 (0.56) | POLBKDM4EALDH1A1HTTCES2 | |
| SCHEMBL7440698 | 0.73 | GAA (0.53) | GRIN1GRIN2BHDAC8KMT2AMEN1 | |
| SCHEMBL7440691 | 0.73 | GAA (0.53) | GRIN1GRIN2BHDAC8KMT2AMEN1 | |
| SCHEMBL4308698 | 0.72 | HDAC8 (0.53) | GRIN1GRIN2BHDAC8KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1133467-B1 | ION CHANNEL MODULATING AGENTS | NEUROSEARCH AS (DK) | 2004-09-15 | — | — | EP | claimed |
| US-20040248099-A1 | Use of intermediate -conductance potassium channels and modulators for diagnosing and treating diseases having disturbed keratinocyte activity | SWITCH BIOTECH AKTIENGESELLSCHAFT (DE) | 2004-12-09 | — | — | US | disclosed |