Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 | Q7Z2W7 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.38 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6668556 | 1.00 | TRPM8 (0.41) | TRPM8KMT2AALDH1A1GAAMAPK1 | |
| SCHEMBL15352733 | 0.74 | CASP1 (0.37) | KMT2AALDH1A1MEN1MAPTKDM4E | |
| SCHEMBL28996726 | 0.73 | TSHR (0.42) | TRPM8KMT2AALDH1A1SMN1; SMN2POLB | |
| SCHEMBL27471455 | 0.71 | POLB (0.43) | KMT2AGAASMN1; SMN2POLBMEN1 | |
| SCHEMBL21588945 | 0.71 | ALDH1A1 (0.47) | TRPM8KMT2AALDH1A1GAASMN1; SMN2 | |
| SCHEMBL15352973 | 0.70 | ALDH1A1 (0.40) | KMT2AALDH1A1MAPK1SMN1; SMN2MEN1 | |
| SCHEMBL15352976 | 0.70 | ALDH1A1 (0.40) | KMT2AALDH1A1MAPK1SMN1; SMN2MEN1 | |
| SCHEMBL14908562 | 0.70 | TSHR (0.41) | TRPM8KMT2AGAASMN1; SMN2POLB | |
| SCHEMBL15352947 | 0.69 | LTB4R2 (0.39) | ALDH1A1SMN1; SMN2MAPTKDM4EHTT | |
| SCHEMBL19668416 | 0.69 | TSHR (0.54) | TRPM8KMT2AALDH1A1GAAMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004030637-A2 | TREATMENT OF OBESITY AND OTHER DISORDERS ASSOCIATED WITH EXCESSIVE FOOD INTAKE | MERCK & CO., INC. (US) | 2004-04-15 | — | — | WO | disclosed |