Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.56 |
| ▸ | HTT | P42858 | 2/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.56 |
| ▸ | APEX1 | P27695 | 1/20 | 0.56 |
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | ELANE | P08246 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | AR | P10275 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29981767 | 0.90 | HTT (0.68) | POLBHTTTDP1APEX1TSHR | |
| SCHEMBL31265922 | 0.90 | HTT (0.68) | POLBHTTTDP1APEX1TSHR | |
| SCHEMBL15084281 | 0.90 | HTT (0.68) | POLBHTTTDP1APEX1TSHR | |
| SCHEMBL15500114 | 0.90 | HTT (0.51) | POLBHTTTDP1APEX1TSHR | |
| SCHEMBL16806094 | 0.89 | POLB (0.45) | POLBHTTTDP1APEX1TSHR | |
| SCHEMBL65218 | 0.88 | POLB (0.51) | POLBHTTTDP1APEX1ELANE | |
| SCHEMBL30971 | 0.87 | ELANE (0.56) | POLBHTTTDP1TSHRELANE | |
| SCHEMBL14173071 | 0.87 | ELANE (0.56) | POLBHTTTDP1TSHRELANE | |
| SCHEMBL346370 | 0.86 | POLB (0.62) | POLBHTTTDP1APEX1TSHR | |
| SCHEMBL6469976 | 0.85 | ELANE (0.42) | POLBHTTTDP1APEX1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1458329-A1 | LOW SHRINKAGE DENTAL COMPOSITE | Bisco, Inc. (US) | 2004-09-22 | — | — | EP | disclosed |
| US-6709271-B2 | SPHERICAL FILLER PORTION TO REDUCE SHRINKAGE AFTER IRRADIATION POLYMERIZATION | BISCO, INC. | 2004-03-23 | — | — | US | disclosed |
| US-20030175660-A1 | Low shrinkage dental composite | BISCO, INC. | 2003-09-18 | — | — | US | disclosed |
| WO-2003043589-A1 | LOW SHRINKAGE DENTAL COMPOSITE | BISCO, INC. (US) | 2003-05-30 | — | — | WO | disclosed |