Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.49 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.49 |
| ▸ | GSK3B | P49841 | 1/20 | 0.46 |
| ▸ | HTR1A | P08908 | 1/20 | 0.45 |
| ▸ | DRD2 | P14416 | 1/20 | 0.45 |
| ▸ | HTR7 | P34969 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | CASP1 | P29466 | 1/20 | 0.45 |
| ▸ | CASP7 | P55210 | 1/20 | 0.45 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6629939 | 0.89 | MAPT (0.50) | MAPTGAAGSK3BALDH1A1KDM4E | |
| SCHEMBL6625944 | 0.88 | ALDH1A1 (0.48) | MAPTHSD17B10GAAALOX15ALOX12 | |
| SCHEMBL6625470 | 0.88 | MAPT (0.52) | MAPTHSD17B10ALOX12ALDH1A1KDM4E | |
| SCHEMBL6625004 | 0.87 | GSK3B (0.45) | MAPTHSD17B10GAAGSK3BALDH1A1 | |
| SCHEMBL6628598 | 0.87 | MAPT (0.51) | MAPTHTR1ADRD2HTR7ALDH1A1 | |
| SCHEMBL6625012 | 0.86 | CNR1 (0.46) | MAPTGAAALOX12HTR1ADRD2 | |
| SCHEMBL6626307 | 0.85 | MAPT (0.52) | MAPTHSD17B10GAAALOX15ALDH1A1 | |
| SCHEMBL6626132 | 0.85 | ADAM17 (0.42) | MAPTGAAALOX15GSK3BALDH1A1 | |
| SCHEMBL6625246 | 0.82 | HTT (0.49) | MAPTGAAALOX12ALDH1A1MEN1 | |
| SCHEMBL6626671 | 0.82 | RAD51 (0.47) | MAPTGAAHTR1ADRD2HTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1373219-A1 | THIOHYDANTOINS AND USE THEREOF FOR TREATING DIABETES | LABORATOIRES FOURNIER S.A. (FR) | 2004-01-02 | — | — | EP | disclosed |
| WO-2002081453-A1 | THIOHYDANTOINS AND USE THEREOF FOR TREATING DIABETES | LABORATOIRES FOURNIER SA (FR) | 2002-10-17 | — | — | WO | disclosed |