Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FDPS | P14324 | 15/20 | 0.57 |
| ▸ | GGPS1 | O95749 | 6/20 | 0.57 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.54 |
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.46 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.46 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.46 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.42 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Neridronic Acid SCHEMBL10764519 | 0.89 | FDPS (0.76) | FDPSGGPS1PDE3ALMNAADRB3 | |
| SCHEMBL19043007 | 0.84 | FDPS (0.52) | FDPSGGPS1PDE3ALMNAADRB3 | |
| SCHEMBL15452862 | 0.83 | FDPS (0.76) | FDPSGGPS1PDE3ALMNAADRB3 | |
| SCHEMBL9313278 | 0.81 | FDPS (0.77) | FDPSGGPS1PDE3ALMNAADRB3 | |
| SCHEMBL11323262 | 0.80 | LMNA (0.50) | PDE3ALMNATSHRNFKB1PMP22 | |
| SCHEMBL10360953 | 0.79 | LMNA (0.44) | FDPSGGPS1PDE3ALMNATSHR | |
| SCHEMBL9313105 | 0.79 | FDPS (0.74) | FDPSGGPS1PDE3ALMNAADRB3 | |
| SCHEMBL10360946 | 0.78 | TSHR (0.46) | FDPSGGPS1PDE3ALMNATSHR | |
| SCHEMBL28040704 | 0.77 | LMNA (0.46) | PDE3ALMNATSHRNFKB1PMP22 | |
| Adipic Acid SCHEMBL4637028 | 0.75 | LMNA (0.73) | PDE3ALMNATSHRNFKB1PMP22 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0831845-B1 | DIPHOSPHONATE DERIVATIVES OF THERAPEUTIC AGENTS | ELIZANOR BIOPHARMACEUTICALS IN (US) | 2004-09-08 | — | — | EP | disclosed |
| US-5854227-A | Therapeutic derivatives of diphosphonates | ELIZANOR BIOPHARMACUETICALS, INC. | 1998-12-29 | — | — | US | disclosed |
| WO-1996040156-A1 | DIPHOSPHONATE DERIVATIVES OF THERAPEUTIC AGENTS | ELIZANOR BIOPHARMACEUTICALS, INC. (US) | 1996-12-19 | — | — | WO | disclosed |