Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARA | P10276 | 4/20 | 0.38 |
| ▸ | RARB | P10826 | 4/20 | 0.38 |
| ▸ | RARG | P13631 | 4/20 | 0.38 |
| ▸ | RXRA | P19793 | 2/20 | 0.37 |
| ▸ | HNF4A | P41235 | 2/20 | 0.37 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.33 |
| ▸ | CYP26B1 | Q9NR63 | 1/20 | 0.33 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9142284 | 0.81 | RXRA (0.41) | RARARARBRARGRXRAHNF4A | |
| SCHEMBL8884872 | 0.81 | CYP26A1 (0.42) | RARARARBRARGRXRAHNF4A | |
| SCHEMBL9137414 | 0.80 | RXRA (0.39) | RARARARBRARGRXRAHNF4A | |
| SCHEMBL9139421 | 0.76 | RXRA (0.37) | RARARARBRARGRXRAHNF4A | |
| SCHEMBL6664143 | 0.76 | RXRA (0.37) | RARARARBRARGRXRAHNF4A | |
| SCHEMBL9817878 | 0.73 | RXRA (0.44) | RARARARBRARGRXRAHNF4A | |
| SCHEMBL7817655 | 0.73 | ACACB (0.32) | RARARARBRARGRXRAHNF4A | |
| SCHEMBL9136509 | 0.72 | RARB (0.36) | RARARARBRARGRXRAHNF4A | |
| SCHEMBL10571276 | 0.71 | RARA (0.46) | RARARARBRARGRXRAHNF4A | |
| SCHEMBL6664577 | 0.70 | CYP26A1 (0.41) | RARARARBRARGRXRAHNF4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0785782-B1 | USE OF DISUBSTITUTED ACETYLENES BEARING HETEROAROMATIC AND HETEROBICYCLIC GROUPS HAVING RETINOID-LIKE ACTIVITY | ALLERGAN INC (US) | 2004-09-08 | — | — | EP | disclosed |