Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 2/20 | 0.56 |
| ▸ | SRC | P12931 | 1/20 | 0.56 |
| ▸ | FNTA | P49354 | 4/20 | 0.56 |
| ▸ | FNTB | P49356 | 4/20 | 0.56 |
| ▸ | KIF11 | P52732 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | HTR2C | P28335 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | HTR6 | P50406 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | CASP1 | P29466 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7127234 | 0.80 | EGFR (0.63) | EGFRSRCMAPTCYP3A4ALDH1A1 | |
| SCHEMBL29915686 | 0.80 | EGFR (0.63) | EGFRSRCMAPTCYP3A4ALDH1A1 | |
| SCHEMBL28405021 | 0.80 | EGFR (0.55) | EGFRSRCMAPTDRD2HTR2A | |
| SCHEMBL4257337 | 0.79 | EGFR (0.61) | EGFRSRCFNTAFNTBDRD2 | |
| SCHEMBL6669751 | 0.77 | KDM4E (0.68) | EGFRSRCFNTAFNTBMAPT | |
| SCHEMBL11494180 | 0.76 | HTR2A (0.67) | FNTAFNTBMAPTCYP3A4DRD2 | |
| SCHEMBL3221608 | 0.74 | EGFR (0.59) | EGFRSRCFNTAFNTBKIF11 | |
| SCHEMBL30892018 | 0.74 | MAPT (0.47) | FNTAFNTBKIF11MAPTALDH1A1 | |
| SCHEMBL6669729 | 0.73 | EGFR (0.63) | EGFRSRCFNTAFNTBMAPT | |
| SCHEMBL18301165 | 0.73 | EGFR (0.63) | EGFRSRCFNTAFNTBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1324985-A4 | INHIBITORS OF PRENYL-PROTEIN TRANSFERASE | MERCK & CO INC (US) | 2004-10-06 | — | — | EP | disclosed |
| EP-1324985-A1 | INHIBITORS OF PRENYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 2003-07-09 | — | — | EP | disclosed |
| WO-2002028831-A1 | INHIBITORS OF PRENYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 2002-04-11 | — | — | WO | disclosed |