Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 2/20 | 0.63 |
| ▸ | SRC | P12931 | 1/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | GPR3 | P46089 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | DRD2 | P14416 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | DRD4 | P21917 | 1/20 | 0.38 |
| ▸ | DRD3 | P35462 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | HTR6 | P50406 | 1/20 | 0.36 |
| ▸ | CASP1 | P29466 | 1/20 | 0.36 |
| ▸ | CASP7 | P55210 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7127234 | 0.79 | EGFR (0.63) | EGFRSRCALDH1A1MAPTCYP3A4 | |
| SCHEMBL18301165 | 0.79 | EGFR (0.63) | EGFRSRCALDH1A1GPR3HSD17B10 | |
| SCHEMBL29915686 | 0.79 | EGFR (0.63) | EGFRSRCALDH1A1MAPTCYP3A4 | |
| SCHEMBL4257337 | 0.77 | EGFR (0.61) | EGFRSRCDRD2HTR2AHTR2C | |
| SCHEMBL3221608 | 0.76 | EGFR (0.59) | EGFRSRCALDH1A1GPR3HSD17B10 | |
| SCHEMBL27902947 | 0.76 | HTT (0.51) | ALDH1A1GPR3HSD17B10MAPTCYP3A4 | |
| SCHEMBL5144476 | 0.75 | EGFR (0.58) | EGFRSRCALDH1A1GPR3HSD17B10 | |
| SCHEMBL2012674 | 0.73 | KDM4E (0.61) | EGFRSRCALDH1A1HSD17B10MEN1 | |
| SCHEMBL6669255 | 0.73 | EGFR (0.56) | EGFRSRCALDH1A1MAPTCYP3A4 | |
| SCHEMBL18932936 | 0.73 | CHRNB2 (0.60) | EGFRSRCALDH1A1HSD17B10MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1324985-A4 | INHIBITORS OF PRENYL-PROTEIN TRANSFERASE | MERCK & CO INC (US) | 2004-10-06 | — | — | EP | disclosed |
| EP-1324985-A1 | INHIBITORS OF PRENYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 2003-07-09 | — | — | EP | disclosed |
| WO-2002028831-A1 | INHIBITORS OF PRENYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 2002-04-11 | — | — | WO | disclosed |