Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | RAB9A | P51151 | 5/20 | 0.43 |
| ▸ | NPC1 | O15118 | 4/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.41 |
| ▸ | RELA | Q04206 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.39 |
| ▸ | HCRTR2 | O43614 | 3/20 | 0.38 |
| ▸ | AVPR2 | P30518 | 3/20 | 0.38 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | SLC12A2 | P55011 | 1/20 | 0.37 |
| ▸ | WNK1 | Q9H4A3 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 3/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6809605 | 0.92 | MAPT (0.47) | MAPTALDH1A1RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL6669291 | 0.86 | MAPT (0.48) | MAPTALDH1A1RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL7080609 | 0.80 | CYP3A4 (0.42) | MAPTALDH1A1RAB9ANPC1POLB | |
| SCHEMBL6801575 | 0.78 | MAPT (0.53) | MAPTALDH1A1RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL6670249 | 0.76 | MAPT (0.42) | MAPTALDH1A1RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL6804886 | 0.75 | SMO (0.50) | MAPTRAB9ANPC1SMN1; SMN2CREBBP | |
| SCHEMBL6668770 | 0.74 | SMN1; SMN2 (0.65) | MAPTALDH1A1RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL6666524 | 0.73 | SMO (0.51) | — | |
| SCHEMBL6667068 | 0.73 | MAPT (0.43) | MAPTRAB9ANPC1SMN1; SMN2POLB | |
| SCHEMBL6666569 | 0.72 | SMO (0.44) | TRPV4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1383760-A1 | BIARYLCARBOXAMIDE COMPOUNDS AS APOLIPOPROTEIN B INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2004-01-28 | — | — | EP | disclosed |
| WO-2002090347-A1 | AMIDE COMPOUNDS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2002-11-14 | — | — | WO | disclosed |