Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.57 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.57 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.57 |
| ▸ | NQO2 | P16083 | 2/20 | 0.55 |
| ▸ | NPC1 | O15118 | 6/20 | 0.55 |
| ▸ | RAB9A | P51151 | 6/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | TP53 | P04637 | 3/20 | 0.55 |
| ▸ | MAPT | P10636 | 3/20 | 0.55 |
| ▸ | POLB | P06746 | 3/20 | 0.55 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.55 |
| ▸ | STAT1 | P42224 | 1/20 | 0.55 |
| ▸ | FYN | P06241 | 1/20 | 0.55 |
| ▸ | RAD52 | P43351 | 1/20 | 0.55 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.55 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.55 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5186798 | 0.86 | MGLL (0.47) | HSD17B1HSD17B2NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL11227834 | 0.84 | CYP17A1 (0.56) | HSD17B10NQO2NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL28742509 | 0.83 | HSD17B10 (0.66) | HSD17B10HSD17B1HSD17B2NQO2NPC1 | |
| SCHEMBL7705979 | 0.83 | ALDH1A1 (0.58) | HSD17B10HSD17B1HSD17B2NQO2NPC1 | |
| SCHEMBL13680541 | 0.81 | HSD17B10 (0.79) | HSD17B10HSD17B1HSD17B2NQO2NPC1 | |
| SCHEMBL12318239 | 0.81 | NPC1 (0.62) | HSD17B10NQO2NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL3786463 | 0.81 | NQO2 (0.73) | HSD17B10HSD17B1HSD17B2NQO2NPC1 | |
| SCHEMBL11232425 | 0.80 | FYN (0.58) | HSD17B10HSD17B1HSD17B2NQO2NPC1 | |
| SCHEMBL11216528 | 0.80 | CYP17A1 (0.54) | HSD17B10HSD17B1HSD17B2NQO2NPC1 | |
| SCHEMBL12999591 | 0.80 | NPC1 (0.69) | HSD17B10HSD17B1HSD17B2NQO2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0056260-A1 | Pyridinyl-substituted-benz imidazole derivatives and preparation | STERLING DRUG INC. (US) | 1982-07-21 | — | — | EP | disclosed |
| EP-0055453-A2 | 5-(Pyridinyl)-benzimidazole derivatives and preparation | STERLING DRUG INC. (US) | 1982-07-07 | — | — | EP | disclosed |
| US-4335132-A | 5-(Py-Y)-1H-benzimidazol-2-ols and 5-(Py-Y-)-1H-benzimidazole-2-thiols | STERLING DRUG, INC. (US) | 1982-06-15 | — | — | US | disclosed |
| US-4331671-A | 5-(Pyridinyl)-1H-benzimidazoles and 1-hydroxy-6-(pyridinyl)-1H-benzimidazoles and their cardiotonic use | STERLING DRUG INC. (US) | 1982-05-25 | — | — | US | disclosed |
| US-4118557-A | Cyclic alkylidenyl N-(lower-alkyl)-3-(pyridinyl)anilinomethylenemalonates | STERLING DRUG INC. (US) | 1978-10-03 | — | — | US | disclosed |