SCHEMBL6670127

SCHEMBL6670127

COn1c(=O)c2cc(F)c(F)cc2n(C2(C)CC2)c1=O

nearest known ligand 0.35

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
PARG Q86W56 2/20 0.35
SMN1; SMN2 Q16637 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6668697 0.61 CA9 (0.59) PARGSMN1; SMN2
SCHEMBL13819109 0.60 PARG (0.54) PARGSMN1; SMN2
SCHEMBL12541553 0.59 ALDH1A1 (0.46) SMN1; SMN2
SCHEMBL6798609 0.54 SRC (0.41) PARGSMN1; SMN2
SCHEMBL4503078 0.54 MPO (0.40)
SCHEMBL3344439 0.52 PGR (0.39) SMN1; SMN2
SCHEMBL15443143 0.51 SMN1; SMN2 (0.41) SMN1; SMN2
SCHEMBL8882694 0.49 TP53 (0.40)
SCHEMBL12040291 0.49
Methoxymethane SCHEMBL27515381 0.48 ALDH1A1 (0.35)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1401830-A2 QUINAZOLINEDIONES AS ANTIBACTERIAL AGENTS Warner-Lambert Company LLC (US) 2004-03-31 EP disclosed
WO-2002102793-A2 QUINAZOLINEDIONES AS ANTIBACTERIAL AGENTS WARNER-LAMBERT COMPANY LLC (US) 2002-12-27 WO disclosed