Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | HTR1A | P08908 | 3/20 | 0.40 |
| ▸ | HTR7 | P34969 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | AKT1 | P31749 | 2/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.36 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6672515 | 0.84 | AKT1 (0.40) | AKT1 | |
| SCHEMBL6672242 | 0.84 | AKT1 (0.40) | AKT1 | |
| SCHEMBL6672759 | 0.82 | DRD2 (0.46) | — | |
| SCHEMBL6673179 | 0.79 | POLB (0.42) | HTR7LMNA | |
| SCHEMBL6669410 | 0.74 | MC4R (0.42) | — | |
| SCHEMBL6397610 | 0.74 | OPRL1 (0.47) | TP53HTR1AHTR7OPRM1OPRL1 | |
| SCHEMBL6397606 | 0.74 | OPRL1 (0.47) | TP53HTR1AHTR7OPRM1OPRL1 | |
| Hydrochloric Acid SCHEMBL6396517 | 0.74 | OPRL1 (0.46) | TP53HTR1AHTR7OPRM1OPRL1 | |
| SCHEMBL6674849 | 0.73 | NOTUM (0.38) | — | |
| Hydrochloric Acid SCHEMBL6669828 | 0.71 | HTR2A (0.36) | LMNAOPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1399432-A1 | SPIROPIPERIDINE COMPOUNDS AS LIGANDS FOR ORL-1 RECEPTOR | PFIZER INC. (US) | 2004-03-24 | — | — | EP | disclosed |
| WO-2003000677-A1 | SPIROPIPERIDINE COMPOUNDS AS LIGANDS FOR ORL-1 RECEPTOR | PFIZER PHARMACEUTICALS INC. (JP) | 2003-01-03 | — | — | WO | disclosed |